The Fate of Glycogen in Diabetes. 39 



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The fate of parenterally introduced glycogen in human and 

 experimental diabetes. 



By Robert A. Cooke. 



[From the Laboratory of Chemical Pathology, Cornell University 

 Medical School.] 



It has been shown by F. Voit and P. Mayer that glycogen 

 parenterally introduced into the normal body of man or lower 

 animal, is utilized, there being no elimination of glycogen, dextrin 

 or glucose in the urine. Mendel repeated this work with rabbits, 

 cats and dogs and found, on the contrary, that 5 per cent, to 18 

 per cent, of the glycogen introduced was eliminated as a dextrin 

 over a period of two days. 



In human and experimental pancreas diabetes the administra- 

 tion of glycogen gave the following results: 

 I. Human diabetes, first trial, E. P., age 16 yrs., wgt. no lbs. 

 Glycogen subcutaneously, 28.0 gm. 

 Glycogen in urine as glue. 28.0 gm. 

 Elimination time, under 24 hours. 

 II. Human diabetes, second trial (same case). 

 Glycogen subcutaneously, 21.5 gm. 

 Glycogen in urine as glue. 21.5 gm. 

 Elimination time under 24 hours. 



III. Complete pancreas extirpation; bitch, 8.5 kilos. 



Glycogen intraperitoneally, 9.5 gm. 



Glycogen recovered in urine as glucose 6.0 gm. = 66 per 

 cent. 



Glycogen recovered in urine as dextrin 3.5 gm. = 34 per 

 cent. 



Elimination time under 24 hours. 



IV. Complete pancreas extirpation; bitch, 14.5 kilos. 



Glycogen intraperitoneally, 25 gm. 



Glycogen recovered in urine as glucose, 22.0 gm. = 88 per 

 cent. 



Glycogen recovered in urine as dextrin, 3.0 gm. = 12 per 

 cent. 



Elimination time under 22 hours. 



