94 



Scientific Proceedings (52). 



it was of moderate degree and resulted in an As-Vs ratio of 2 : 1 

 or 3 : 1. In another it was severe; except occasionally, the ven- 

 tricles received no impulses from auricular contractions, but main- 

 tained the circulation by idioventricular contractions in complete 

 dissociation with those of the auricles. All the dogs recovered. 



The conclusions are warranted: that morphine stimulation of 

 the vagus center in dogs having one vagus nerve only has the same 

 effect as faradic stimulation of the same nerve in other dogs; 

 that the results of the morphine method substantiates a former 

 conclusion based on faradic stimulation that characteristic differ- 

 ences between the two vagi exist; and that the lack of uniformity 

 found by Einthoven in the arhythmia of the heart obtained on 

 morphine injections is only apparent and is capable of analysis. 



64 (760) 



The influence of temperature on the minimal dose of strychnin 

 in frogs and on the time of onset of tetanus. 



By T. S. Githens. 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute.] 



Rana pipiens were used exclusively and all injections were 

 given in the dorsal lymph sac. Temperatures from 40 0 F. to 

 8o° F. were studied. With doses of 0.0006 mg. per gm. (about 

 O.02 mg. for a 30 gm. frog) tetanus was constantly obtained at all 

 temperatures. With doses of 0.0005 mg. per gm. (about 0.015 

 mg. per frog) strong tetanus was obtained constantly at tempera- 

 tures about 40 0 F. and about 8o° F. It was occasionally seen at 

 55 0 F. and never at temperatures from 65 0 to 75° F. With doses 

 of 0.0003 m g- P er g m - strong tetanus was constant about 40 0 F. 

 and occurred frequently at 8o° F., but was never seen at tempera- 

 tures from 55 0 F. to 70 0 F. 



In regard to the time elapsing before tetanus; with minimal 

 doses it is very variable but on the whole is less the higher the 

 temperature. Thus with a dose of 0.0006 mg. per gm. tetanus 

 came on at 40 0 after K to 4 hours; at 55 0 after 1 to 2^ hours; at 

 70 0 after % to 2 hours; and at 85 0 after H to 1 hour. With a 



