Grehant's Anesthetic and Morphine-Ether. 95 



dose of 0.001 mg. per gm. tetanus came on at 40 0 after M to 4 

 hours; at 55 0 after % to i}i hours; at 70 0 after H to % hours. 



These results show that tetanus may be induced by strychnin 

 at low and at high temperatures by doses which will not cause 

 tetanus at temperatures between. They also show that the inter- 

 val between injection and the onset of tetanus grows less with 

 higher temperatures, although there is no constant ratio. 



65 (76i) 



On the difference in the effect of Grehant's 1 anesthetic and of 

 morphine-ether on the total output of urine and the 

 composition of the urine in normal dogs. 



By Wm. deB. MacNider. 



[From the Laboratory of Pharmacology, University of North Carolina.] 



In a recent study of the action of various diuretics in uranium 

 nephritis, 2 it was shown that the anesthetic employed in the experi- 

 ments not only influenced the output of urine, but that following 

 the anesthetic, diuretic substances such as caffeine, theobromine, 

 and 0.9 per cent, sodium chloride lost their diuretic value. 



The following experiments are being conducted to ascertain 

 if the previously mentioned anesthetics have any effect in reducing 

 the output and in changing the composition of the urine in the 

 normal dog and if the anesthetics differ from one another in their 

 action. 



When full grown dogs are given Grehant's anesthetic in the 

 strength usually employed there is a marked reduction in the 

 output of urine and the animal becomes glycosuric, the percentage 

 of glucose varying between 0.165-3.33 per cent. Acetone has so 

 far been constantly present in the urine of these full-grown 

 animals. 



An albuminuria is induced and is accompanied by the appear- 

 ance of casts, hyaline, or hyaline and granular. In one of the 



1 Grehant's anesthetic. The animal is given c.c. per kilogram of a 4 per cent, 

 solution of morphine. This is followed in half an hour by 10 c.c. per kilogram of the 

 following mixture: chloroform, 50 c.c; alcohol and water, each 500 c.c. 



2 The Journal of Pharmacology and Experimental Therapeutics, Vol. Ill, No. 4, 

 March, 1912. 



