100 



Scientific Proceedings (52). 



68 (764) 



Metabolism studies in a case of hypopituitarism, with 

 infantilism of the Lorain type. 



By DeWitt Stetten and Jacob Rosenbloom. 



[From the German Hospital, New York, and the Laboratory of Bio- 

 chemistry of the University of Pittsburgh, Pittsburgh, Pa.] 



This report contains the results obtained on studying certain 

 phases of metabolism in a case of a man aged 22, who presented 

 the classical symptoms of infantilism of the Lorain type, with 

 symptoms definitely pointing to a benign tumor, probably a cyst 

 of the hypophysis. 1 The arrest of the body growth and of sexual 

 development with the moderate adiposity stamped this case as a 



Table I. (Nitrogen Partition.) 

 Urine. 





a 



1 



Urea- 

 Nitrogen. 



Ammonia- 

 Nitrogen. 



Creatinine- 

 Nitrogen. 



Uric Acid- 

 Nitrogen. 



Undeter- 

 mined-Nitro- 

 gen. 



Date 



0 

 H 



6 

 O 



Per Cent, of 

 Total 

 Nitrogen. 



i 



O 



Per Cent, of 

 Total 

 Nitrogen. 



g 

 O 



Per Cent, of 

 Total 

 Nitrogen. 



S 



O 



Per Cent, of 

 Total 

 Nitrogen. 



a 



0 



Per Cent, of 

 Total 

 Nitrogen. 



6/23 

 6/26 

 6/27 

 6/28 

 6/29 

 6/30 

 7/1 



13.O 

 16.1 

 16.3 

 15.7 

 15-8 

 15-3 

 15-7 



13-5 

 13-3 

 12.6 

 12.9 

 12.3 

 12.6 



83.8 

 81.6 

 80.3 

 81.7 

 80.5 

 80.2 



O.36 

 O.41 

 O.40 

 O.44 

 O.40 

 O.48 



2-3 

 2-5 

 2-5 



2- 7 

 2.6 



3- 1 



O.60 

 O.58 

 O.56 

 0-54 

 0.50 

 0-55 



3-8 



3-5 

 3-5 

 3-4 

 3-3 

 3-5 



0.20 

 O.24 

 0.26 

 O.23 

 O.27 

 O.29 



1.4 

 1.5 

 1-7 

 1.5 

 1-7 

 1.9 



1.4 

 1.8 

 1.9 



i-7 

 1.8 

 1.8 



8-7 

 II. 0 

 12. 1 

 10.8 



11. 7 

 ii-5 



Table II. (Sulphur Partition.) 

 Urine. 



Date. 



Total 

 Sulphur 

 Gm. 



Total 

 Sul- 

 phate 

 Sul- 

 phur, 

 Gm. 



Ethereal 



Sul- 

 phate 



Sul- 

 phur, 



Gm. 



Inor- 

 ganic 



Sul- 

 phate 



Sul- 

 phur, 



Gm. 



Neutral 

 Sul- 

 phur 

 Gm. 



Sulphate-S 



Ethereal 

 Sulfate-S 



Inorg. Sulf. 



s 



Neut. S, 

 Total S. 



Per 

 Cent. 



Total S 

 Per Cent. 



Total S 

 Per Cent. 



Total S 

 Per Cent. 



6/23 



0.57 



0.45 



O.04 



0.41 



0.12 



78.6 



6.8 



71.8 



21.3 



6/26 



O.41 



O.30 



O.03 



O.27 



O.II 



72.5 



7.2 



653 



27.4 



6/27 



O.80 



0.66 



0.06 



O.60 



O.14 



82.4 



7-1 



75-3 



17-5 



6/28 



O.90 



0.69 



O.04 



O.65 



0.21 



76.7 



4-3 



72.4 



23-3 



6/29 



O.90 



0.69 



O.05 



O.64 



0.21 



76.7 



5-5 



71.1 



23-3 



6/30 



O.87 



0-53 



O.05 



O.48 



0-34 



61.7 



6.4 



55-3 



38.3 



7/i 



O.96 



0.66 



0.04 



O.63 



0.30 



69.2 



4.0 



65.2 



30.8 



At operation a cyst of the hypophysis was found. 



