Relation of Pancreatic Extract to Sugar. ioi 



typical example of the Froehlich typus or the so-called dystrophia 

 adiposo-genitalis of Bartels. 



The patient was placed on the high protein diet of Folin and 

 the following tables contain the data obtained in this study. 

 The high undetermined nitrogen and neutral sulphur of the urine, 

 can readily be noted, while the absorption of fat and protein 

 was normal. 



Table III. 



Summary of data pertaining to total nitrogen and fat metabolism. 





Total Nitrogen. 



Feces. 



Fat. 



Date. 











Total Nitrogen. 



In- 

 gested, 

 Grams. 



Percent- 



Ingested, 

 Grams. 



Excreted. 

 Grams. 



Balance. 

 Grams. 



Fat, 

 Grams. 



Found, 

 Grams. 



Per Cent, 

 of Total N 

 Ingested. 



age of 

 Fat Ab- 

 sorbed. 



6/26 

 6/27 

 6/28 

 6/29 

 6/30 

 7/1 



18.2 

 18.6 

 18.3 

 I8.I 

 17.6 

 17.8 



17.9 

 18. 1 

 17-5 

 17.9 

 17.4 

 17.8 



+0.3 

 +0.5 

 +0.8 

 +0.2 

 +0.2 

 0 



2.2 

 2.2 

 2.2 

 1.8 

 1.8 

 1.8 



1.8 

 1.8 

 1.8 

 2.1 

 2.1 

 2.1 



9.9 

 9-7 

 9.9 

 11.6 

 11.9 

 11.9 



140 

 140 

 140 

 146 

 146 

 146 



98.4 

 98.4 

 98.4 

 98.8 

 98.8 

 98.8 



Total 



108.6 



106.6 



+ 2.0 



12.00 



11.70 





858 





Average 



18. 1 



17.7 + 



+0.33 



2.00 



1-95 



10.8 



143 



98.6 



69 (76s) 



The relation of pancreatic extract to the sugar of the blood. 

 By Ernest L. Scott. 



[From the Department of Physiology of Columbia University.] 



In January, 1912, I reported a preparation of pancreas which 

 when injected intravenously into dogs that had been rendered 

 diabetic by pancreatectomy, lowered both the output of sugar 

 and the D/N ratio. This preparation seemed to offer a ready 

 means of attack for several of the problems bearing on the relation 

 of the pancreas to sugar metabolism. Possibly the simplest of 

 these is the relation between the amount of sugar present in the 

 blood and the abundance of the pancreatic hormone present, and 

 this is a preliminary report of my work on this subject. 



Cats were killed and their blood was collected. The protein 

 was removed and the blood was decolorized by a modification of 

 the phosphotungstic acid method reported by Oppler. In deter- 



