Blood Pressor Substances in Immunity. 



105 



Protocol July 13, 1912. — 7 c.c. of serum of same calf, bled 

 June 21, 19 13, gave a fair rise. The extract in saline solution of 

 the adrenal gland of this calf gave a very high rise, 1 /16 c.c. 

 being sufficient to cause a very marked straight rise. 1 7 c.c. of 

 tuberculous (bovine type) dog serum gave no response. This dog 

 was killed and was probably dying according to the autopsy 

 findings. 



Protocol August 28, 1912. — 8 c.c. of serum from a dog, recover- 

 ing according to autopsy findings from tuberculosis (bovine type) 

 gave a fine rise. Repeated with same results three times. 



Protocol January 5, 19 10. — 2 c.c. of the serum from a rabbit 

 with tuberculosis, bovine type, gave a fair, sustained rise. 



Protocol April 6, 191 2. — 8 c.c. of serum from a dog recovering 

 from tuberculosis, bovine type, gave a marked rise. Repeated 

 three times. 



8 c.c. of this serum, injected into a dog sensitized with tuber- 

 culin, gave a marked rise, when added to 10 drops of tuberculin 

 No. 5, which ordinarily caused a fall. 



Further observations of the occurrence of pressor substances 

 were made as follows in animals about to die from hydrophobia. 2 



Protocol 16. — 7 c.c. of serum obtained from a rabbit (June 21, 

 191 2), sick with hydrophobia, gave a marked rise. Femoral 

 injection. 



7 c.c. of serum from a goat with hydrophobia gave a slight rise. 

 Femoral injection. 



Protocol March 17, 191 1. — 7 c.c. of serum from a dog with 

 hydrophobia, gave a slight depression. 



Protocol April 8, 191 1. — 5 c.c. of serum of rabid dog, bled 

 April 8, 191 1, gave marked rise. Repeated once. 



4 c.c. of serum from collie with hydrophobia also gave a marked 

 rise. 



7 c.c. from a dog with dumb rabies gave a rise, bled April 5, 

 1911. 



7 c.c. from a dog with rabies (March 17, 191 1) gave a rise. 



1 The extract of the adrenal glands of rabbits which died of tuberculosis showed 

 little or no pressor substance. 



1 We found the pressor substance present in the serum of animals (dog and goat) 

 suffering from street rabies, bled just before their death. These animals with the 

 exception of the rabbit were naturally infected. 



