io6 



Scientific Proceedings (52). 



6 c.c. from a collie with rabies gave a marked rise, bled March 

 24, 191 1. 



Protocol of March 31, 191 1. — 2>Vi c.c. of serum from collie 

 with hydrophobia gave a very marked rise. Repeated three times. 



6 c.c. of serum from fox terrier, with hydrophobia, tested 

 March 17, 191 1, gave a very marked rise. Repeated twice. 



Protocol November 9, 1910. — 1 Y2 c.c. 01 serum from a dog with 

 hydrophobia, bled November 3, 1910, gave a slight rise; 5 c.c. 

 gave a fair rise. 



Protocol January 6, 1912. — 7 c.c. of serum from a hydrophobia 

 dog, of January 2, 191 2, gave a fair rise. 



The apparent contradiction between the recovering tuberculous 

 animal and the dying hydrophobia animal may be explained by our 

 previously reported observations, 1 where the continued injection 

 of a depressor substance instead of causing death led to an actual 

 increase in blood pressure. 2 



It would appear that animals possessing these pressor sub- 

 stances do not die as readily from infection or intoxication as those 

 which do not have these pressor substances. It appears to us 

 that we may have here a general law for many, if not all infections 

 and intoxications. 



We have found two substances in adrenal gland preparations. 



A substance causing increased pressure and a depressor sub- 

 stance. 



In commercial preparations we found these two substances to 

 be present. 



Separations were made by alcohol, ether, chloroform and normal 

 saline solution. 



In saline extracts of fresh glands, the substance causing increased 

 pressure was present alone or so greatly in excess as to dominate 

 the reaction. 



In the adrenals of certain diseased animals (tuberculosis, 



1 Proc. Soc. Exp. Biology and Medicine, 1912, IX, pp. 49-51. 



2 It would also be of interest to study the origin of these pressor substances in 

 normal and diseased tissues. Protocol of January 16, 1913, for example shows 

 that the injection of 5 c.c. normal dog brain extract, gave no response, while the 

 same doses of tuberculous and hydrophobia brain extracts gave a slight rise. These 

 extracts were made with saline solution. 



