Vaccinia Blood Pressor Substances in Rabbits. 137 



that in the combustion of glucose lactic acid may arise from the 

 cleavage of the sugar molecule. On account of this significant 

 place held by lactic acid it appears of interest to investigate the 

 relation it may hold to sugar production in human diabetes. 

 Only cases of diabetes of considerable severity are suitable for 

 the experiment, since in the milder degrees of the human disorder 

 relatively large amounts of carbohydrate may be burned or stored 

 and the sugar output is apt to fluctuate. In a patient it was 

 ascertained that with a uniform diet for three days a fairly constant 

 glucose excretion could be depended upon and lactic acid as the 

 sodium salt was given on the second day of the experimental 

 period with the result that there was a rise in sugar excretion 

 shown by the following abstract from the protocol. 





Amount 

 urine. 



Sugar, 

 grams. 



Total N. 



NH 3 N. 



Acetone and 

 diacetic. 



B-oxy 

 butyric. 



Vegetable diet. . . . 



1. 810 



2.89 



3-62 



1-37 



•78 



0.79 



Oatmeal diet 



1.450 



2.80 



4.80 



1.22 



•59 



1 .41 



Meat diet 



2,300 



6.56 



11.46 



I.42 



.76 



1-77 



15 gm. Na lactate. 



2.010 



19.90 



14.06 



1.S6 



.82 



1.49 





2.050 



2.91 



14.92 



0.71 



.86 



I.97 



91 (787) 



On some vaccinia blood pressor substances in rabbits. 



By J. P. Atkinson and Chas. B. Fitzpatrick, M.D. 



[From the Chemical and Research Laboratories, Department of 

 Health, City of New York.] 

 These notes constitute a continuation of our observations on 

 some blood pressor substances in experimental immunity, reported 

 at the last meeting of this society, and apparently tend to confirm 

 the same. We have endeavored to ascertain when the pressor 

 and depressor substances appeared in the blood serum of living 

 rabbits after they had been successfully infected with vaccinia 

 virus. The height of the production of the vesicles from which 

 the virus was collected was reached on the fifth day. They then 

 rapidly healed and the rabbits appeared outwardly to be in good 

 health. 



Observations were also made to ascertain the effect of aging 

 on the presence of the depressor substance. 



