Influence of Pancreatic and Duodenal Extracts. 171 



and cabbage succumbed to a dose of 0.4 gm. of the salt per kilo 

 when given by subcutaneous injection. Suppression of urine was 

 usually observed on the first day and death occurred in six to 

 seven days. In starvation, slightly smaller doses were fatal to 

 some rabbits. The resistance was increased considerably when 

 the diet was changed to carrots. Such animals stood 1.0 gm. per 

 kilo by subcutaneous injection, while 1 .2-1 .5 gm. per kilo were 

 toxic. A moderate degree of tolerance for tartrates was in- 

 duced in animals which were fed oats and cabbage. By grad- 

 ually increasing the dose, a large proportion (6 out of 9) of rabbits 

 survived 0.8 gm. per kilo which is twice the fatal dose. Rabbits 

 which were receiving carrots did not acquire tolerance for tar- 

 trates. Sodium tartrate was much less toxic when given by 

 mouth. 5 gm. per kilo was found to be the minimum fatal dose. 



Experiments on Cats. 



Amounts which have been found to be fatal for rabbits did 

 not produce any symptoms in cats. Subcutaneous injection of 

 one gm. per kilo produced a slight diarrhea in some individuals, 

 and had no effect whatever in others. \\ gm. per kilo proved 

 fatal to one cat but was without action in another. Out of four 

 cats which received 2 gm. per kilo three died, one survived. When 

 sodium tartrate was given by mouth vomiting frequently occurred. 

 In one case, however, when ten gm. per kilo were fed diarrhea was 

 the only effect observed. 



108 (804) 



The influence of pancreatic and duodenal extracts on the gly- 

 cosuria and the respiratory metabolism of depancreatized dogs. 



By J. R. Murlin and B. Kramer. 



[From the Physiological Laboratory of Cornell University Medical 

 College, New York City.] 



Several dogs completely depancreatized by Hedon's method 

 and eliminating glucose and nitrogen in Minkowski's ratio were 

 treated by intravenous injection of pancreatic extract prepared 

 by Knowlton and Starling's method. 1 The urines collected in 

 twenty-four hour periods exhibited an increase in the D: N ratio 



1 Knowlton and Starling, Journ. of Physiol., 1912, XLV, p. 146. 



