172 



Scientific Proceedings (54). 



on the days immediately following. When the urine was collected 

 in short periods after injection, a marked fall in the sugar output 

 was witnessed lasting from four to ten hours but this was followed 

 by a compensating rise which, in some instances, augmented the 

 total for the twenty-four hour period, in others raised it only to 

 the previous level. 



Much greater effects were obtained with a double extract of 

 dog's pancreas and duodenal mucosa. The following experiment 

 (No. II) is typical. The effect, however, cannot be ascribed to 

 the organic extract from either the pancreas or the duodenum for 

 the same Ringer's solution in which the tissues were extracted 

 when made alkaline to about the same extent with Na 2 C0 3 gave 

 an identical effect. 



Dog "Q." Operated April 17. 

 Exp. II. 



Date. 



Time. 



Vol. 

 urine, 

 c.c. 



Glu- 

 cose, 

 gm. 



Nitro- 

 gen, 

 gm. 



D:N. 



Glucose per 

 hour. 



Nitrogen 

 per hour. 



Blood 

 sugar, 

 per cent. 



4/2I/I3 

 4/22/13 



12.15- 2.15 

 2.15- 4-15 

 5.OO- 5.30 



4.15- 6.15 

 6.15- 7-15 

 7-IS- 8.15 

 8.15- 9-15 

 9.15-IO.15 



P.M. 

 10.15- 6.00 



30 

 50 



150 c. 

 int 



30 

 25 

 26 



26 



22 



2.41 

 2.40 

 of pai 

 ravenoi 

 1.30 

 0.28 

 0.41 

 0-59 

 0.51 



18.66 



0-95 

 I.09 



lcreas a 



isly 

 0.67 

 0-33 

 0-45 

 0.48 

 0-39 



6-99 



2.52 

 2.20 



nd duo< 



1-93 

 0.87 

 0.89 

 1. 21 

 1.28 



2.68 



1.20 

 1.20 



lenum frorr 



0.65 

 0.28 

 0.41 

 o-59 

 0.51 



0.93 



O.47 

 0-54 

 1 2 normal ( 



0.35 

 033 

 0.45 

 0.48 

 0-39 



o-35 



0.128 

 logs inj. 



O.I48 



Exp. III. 



4/24/13 

 4/24-25 



2.10-4.19 

 4.26-5.15 

 4. 19-6. 19 

 6. 19-8. 19 



A.M. 

 8.19-1.19 



22 



150 c. 



60 

 24 



90 



1.6s 

 c. Ring 

 1.65 

 0.46 



2.41 



0.54 

 ;r's Sol. 

 0.64 

 0.52 



0.59 



3.08 | 0.82 

 +i%Na 2 C0 3 inje 

 2.55 I 0.82 

 0.88 0.23 



1.62 j 0.48 



0.27 

 cted intrav 

 0.32 

 0.26 



0.29 



enously 



The similarity in these two experiments on the same dog 

 indicates that it is not a hormone which is responsible for the 

 reduction in the sugar, and the increase in the percentage of sugar 

 in the blood indicates that the reduced sugar elimination is in 

 reality due to a change in the permeability of the kidney, as 

 Wohlgemuth 2 has found it after ligation of the pancreatic ducts. 



That there is no effect on the combustion of sugar attending 



2 Wohlgemuth, Berl. klin. Woch., February 24, 1913, p. 339- 



