174 



Scientific Proceedings (54). 



109 (805) 



The carbon dioxide and oxygen content of the blood after ligation 

 of the abdominal aorta and the inferior vena cava. 



By J. R. Murlin, L. Edelmann and R. C. Giles. 



[From the Physiological Laboratory of Cornell University Medical 

 College, New York City.] 



Respiration experiments on normal and depancreatized anaes- 

 thetized animals after ligation of the abdominal aorta and the 

 inferior vena cava 1 and on normal animals after exclusion of the 

 liver by joining the portal vein to the inferior vena cava 2 show an 

 increase in the respiratory quotient, which is interpreted by the v. 

 Noorden school to demonstrate the combustion of sugar in the 

 depancreatized animal and the dependence of the normal animal 

 upon the liver for its ability to burn protein and fat. These 

 experiments, however, were not accompanied by analyses of the 

 blood gases. It is possible that the higher respiratory quotient 

 after shortening of the circulating stream might be due to an 

 interference with the oxygen absorption (passive congestion of 

 the lungs) or to increased elimination of carbon dioxide by more 

 rapid circulation of the blood through the lungs. 



Preliminary to some respiration experiments on depancreatized 

 dogs in which we are seeking the explanation of the altered res- 

 piratory quotient, we have made a number of experiments on 

 normal dogs analyzing the carotid blood before and after simul- 

 taneous clamping of the abdominal aorta and the inferior vena 

 cava. The results follow: 



Date. 



Dog 

 No. 



r E 



Pulse per min. 



Resp. per min. 



O2 per cent, 

 in blood. 



CO2 per cent, 

 in blood. 



Clamps 

 on. 



Normal. 



Clamped, j 



Normal. 



Clamped. 



Normal. 



Clamped. 



Normal. 



Clamped. 



1913 

























3/22 



I 



8 



108 



140 



36 



30 



14-73 



14.83 



43.16 



22.53 



30 min. 



4/10 



II 



12 



66 



102 



35 



12 



16.40 



16.45 



38.35 



37-47 



23 min. 



4/19 



III 



9 



132 



121 



66 



77 



18.88 



I6.39 



39-42 



24.28 



1 hr. 



5/io 



IV 



10 



108 



120 



33 



15 



12.62 



10.90 



57-06 



34-16 



1 hr. 



1 Porjes, O., Biochem. Zeitschr., 1910, XXVII, p. 131; Porjes and Salomon, idem, 

 p. 143- 



1 Verzar, idem, 1912, XXXIV, p. 52. 



