Influence of Certain Diets Upon Tumors. 175 



Chloretone anaesthesia was used. In the case of the last dog 

 which eliminated about 80 c.c. of C0 2 per minute, it may be 

 estimated that a reduction from 57 to 34 per cent, would remove 

 from the body in the course of one hour, about 800 c.c. of C0 2 or 

 enough to raise the R. Q. from 0.75 to 0.88. It cannot be assumed 

 as Porges has done that the blood gases, under the circumstances, 

 would reach an equilibrium within 10-15 minutes, for with the 

 circulation diminished to one half and the heart beating at its 

 normal rate, or higher, the blood would pour through the lungs 

 twice as often and would continue to lose carbon dioxide until the 

 tension in all the tissues became very much reduced. 



In dog II the compensation in the rate of respiration was almost 

 sufficient to prevent loss of CO2. 



no (806) 



On the influence of certain diets upon the growth of experimental 



tumors. 



By J. E. Sweet, E. P. Corson-White and G. J. Saxon. 



[From the Laboratory of the American Oncologic Hospital, 

 Philadelphia, Pa.] 



The study of the experimental tumors of animals has brought 

 forward numerous interesting observations upon the variation in 

 susceptibility of animals of the same species obtained from different 

 sources, to a given tumor strain, as well as variation in the rate 

 of growth of the transplanted tumors. We have undertaken the 

 study of the relation of certain diets to tumor growth and wish to 

 briefly report the results obtained with a diet based upon the 

 work of Mendel and Osborne. In their studies of the effect of 

 feeding with pure vegetable proteins they encountered numerous 

 combinations which effectively prevented growth, the animal 

 meanwhile appearing in good health. This seemed to us to offer 

 a most interesting opportunity to study the behavior of the tumor 

 cell under these conditions; in other words, regardless of whatever 

 the cause of cancer may be, can an inoculable tumor grow in a 

 host which is apparently incapable of normal cell growth? 



This report, while based on a small series as tumor experi- 

 ments go, shows a result so uniform and striking that its con- 



