i?8 



Scientific Proceedings (54). 



basis adaptation of this order would be due to the production of 

 receptors different from those found in dye susceptible strains, 

 by which the nutrition (sc. reproduction) of the organism could 

 be carried on, and which either possesses no affinity for the dye 

 in question or through which the organism can bring about its 

 cleavage. A limited number of observations would suggest that 

 in the treatment of certain infections, with staphylococci and 

 streptococci more especially, certain dyes might be used to ad- 

 vantage. In two cases of erysipelas the repeated local application 

 of the concentrated solution of dahlia seemed to restrict the exten- 

 sion of the infection. 



112 (808) 



Waxy degeneration of muscle in venom intoxication. 



By Richard M. Pearce, M.D. 



[From the John Herr Musser Department of Research Medicine 

 University of Pennsylvania, Philadelphia.] 



In connection with the discussion by Beneke 1 and Wells 2 of 

 waxy degeneration of muscle occurring in anaphylactic poisoning, 

 and especially in view of Beneke's reference to the action of 

 " brasilianischen Schlangengift " {Crotalus terrificus) the following 

 notes on waxy degeneration in the rabbit following the intravenous 

 injection of the venom of Crotalus adamanteus may be of interest. 



In the course of three series 3 of experiments on a total of 

 about 45 rabbits it was noted that the intravenous injection of 

 venom was followed in three instances by waxy degeneration so 

 well-marked as to be evident macroscopically. In two of the 



1 Beneke, R., "Ueber den Kernikterus der Neugeborenen," Munch, med. 

 Wochenschr., 1912, LIX, 387; "Ueber Muskelveranderungen bei akuten Ver- 

 giftungen mit Klapperschlangengift sowie bei Anaphylaxie," Munch, med. Woch., 

 1 912, LIX, 729; Beneke, R., and Steinschneider, E., "Zur Kenntnis der anaphylak- 

 tischen Giftwirkungen," Cenlralb. f. allg. Path. u. path. Anal., 1912, XXIII, 529. 



2 Wells, H. Gideon, "Anaphylaxie und Wachsartige Degeneration der Muskeln," 

 Centralb. f. allg. Path. u. path. Anal., 1912, XIII, 945. 



3 Pearce, R. M., "An Experimental Study of the Relative Importance of Renal 

 Injury, Vascular Injury and Plethoric Hydremia in the Production of Edema," 

 Arch.}. Int. Med., 1909, III, 422; "An Experimental Glomerular Lesion Caused by 

 Venom (Crotalus Adatnanteus), Jour. Exper. Med., 1909, XI, 532; "Experimental 

 Studies of the Influence of Crotalus Venom on the Kidney," Jour. Exper. Med., in 

 press. 



