44 



Scientific Proceedings (55). 



From the above results it is evident that our original conclu- 

 sions are correct. Cholesterol has an accelerating action on 

 malignant tumor growth, whether it be injected into the tumor, 

 or carried to it by the circulation. 



25 (842) 



Nephritis in ground squirrels (Citellus Beechyi). 



By William Ophuls and George W. McCoy. 



[From the Plague Laboratory of the U. S. Public Health Service at 

 San Francisco and the Pathological Laboratory of the 

 Stanford University Medical Department.] 



In the course of the examination of about 250,000 ground 

 squirrels for plague 6 cases were noted in which there were gross 

 lesions in the kidneys and which on microscopic examination 

 presented evidence of chronic nephritis. 



In one of these the lesions were very much like those in the 

 experimental uranium nephritis of rabbits. There were large 

 areas of cellular infiltration and fibrosis with atrophy of the tubules. 

 The capsules of the glomeruli in these areas were slightly thickened. 

 Some of the glomeruli showed a marked cystic dilatation. Other 

 parts of these kidneys were practically normal except for a partial 

 necrosis of the epithelium. 



Two other specimens resembled closely the type of spontaneous 

 nephritis in wild rats described by us in the Journal of Medical 

 Research (191 2, XXVI, 249). There was the same granular de- 

 generation, necrosis and desquamation of the epithelium in some 

 places with marked regenerative proliferation of the epithelium 

 in others. There was the same tendency to the formation of 

 epithelial cysts. The glomeruli showed some enlargement and 

 proliferation of the capsular epithelium and a slight fibrous thick- 

 ening of the capsule itself. In the interstitial tissue we found 

 irregular areas of cellular infiltration and more or less fibrosis. 



The three remaining cases were the most interesting ones in 

 that they showed an entirely different type of the disease associated 

 with the accumulation in many, usually somewhat dilated, tubules 



