Embolism of the Arterioles. 



45 



of colorless crystalline masses which seem to consist of thick 

 rhomboidal plates closely joined together in the form of rosettes. 

 Sometimes they are so tightly packed as to form solid spherical 

 bodies. One of us (Ophiils) has observed similar deposits in a 

 human kidney in a case in which the renal pelvis was filled with 

 large stones, apparently composed largely of urates. It seems 

 most likely that these deposits are also deposits of urates. No 

 evidence of stone formation in the pelvis was however present in 

 the squirrels. The histological lesions in the squirrels are also 

 similar to those in the human case mentioned. They involve the 

 interstitial tissue very largely and have caused, in two cases 

 especially, a very extensive development of cellular connective 

 tissue with much destruction of kidney substance. The glomeruli 

 in these areas show a slight fibrous thickening of their capsules. 

 The rest of the tubules were normal except in one case in which 

 there was some degeneration and evidences of proliferation in the 

 tubules, similar to that found in the second type which resembles 

 rat nephritis. 



It is hardly necessary to say that arterial lesions were carefully 

 searched for but there was no evidence of them in any of the 

 specimens. 



26 (843) 



Experimental embolism of the arterioles in guinea pigs with 

 hardened erythrocytes of Triton (Diemy Aylus) torosus and 

 of Chondrotus tenebrosus. 



By W. Ophuls. 



[From the Laboratory of Pathology of the Medical School of Leland 

 Stanford Junior University, San Francisco.] 



The experiments were suggested by a desire to determine 

 experimentally the changes, if there are any, which follow the com- 

 plete obstruction of the vasa afferentia of the glomeruli of the 

 kidney in mammals. A blocking of such small vessels may be 

 accomplished by the use of the large erythrocytes of newts or 

 salamanders which may be conveniently hardened in Orth's fluid, 

 then washed in water, suspended in sterile salt solution and injected 



