4 6 



Scientific Proceedings (55). 



by means of a hypodermic syringe directly into the left ventricle. 

 The corpuscles after hardening measure about 32 X 12 micromm. 



It is necessary to inject a rather heavy suspension of the cor- 

 puscles, otherwise so few glomeruli become obstructed that it is 

 difficult to find them in sections; on the other hand, as most of the 

 corpuscles are carried into the brain, convulsions and death are apt 

 to occur if too many are introduced into the arterial circulation. 



In the spleen the corpuscles lodge in the central arterioles of 

 the Malpighian bodies and do not cause any lesions. 



I have never been able to find the corpuscles in liver or lungs 

 in spite of the study of many serial sections. 



In the kidneys also they are not very numerous as a rule, the 

 careful study of serial sections being required to find them. They 

 block the vas afferens completely, but in spite of this the glomerulus 

 remains absolutely intact and no histologic lesions follow elsewhere 

 in the renal tissues. This would make it very improbable that the 

 collapse and fibrosis of the glomeruli in arteriosclerosis is due 

 directly to the mechanical obstruction of the vasa afferentia by the 

 arteriosclerotic process. 



In the brain the corpuscles are much more numerous both in 

 the cortex and basilar ganglia. Curiously enough in brain sections 

 of an animal which was examined a month after the injection the 

 foreign corpuscles appear to lie outside of the blood-vessels in the 

 perivascular lymph spaces which would suggest a degree of per- 

 meability of these vessels hitherto unsuspected. Apart from 

 doubtful degenerative processes in some of the cells, there were no 

 lesions in the central nervous system either. 



If it should be of any physiological importance, the method 

 might be used to determine by a proper selection of corpuscles the 

 exact size of the arterial capillaries while fully distended under 

 normal blood pressure. 



