Internal Secretion of Pancreas. 



7i 



The section of the nerve was performed in January, 191 3, and 

 sensibility, at the time of writing, is not yet normal. It is, there- 

 fore, too early to present any definite conclusions. In general, 

 however, the following points, subject to such modification in 

 details as a subsequent working over of the data in the light of the 

 completed experiment may necessitate, may be noted: (1) The 

 section of the cutaneous nerve did not destroy the sensibility of 

 the subcutaneous tissue, which provided to a considerable extent 

 the capacity for localization. (2) With the exception of certain 

 early general pains, that were probably, strictly speaking, not of 

 cutaneous origin, it may be said that the return of warmth, cold, 

 pressure, and pain began at approximately the same time. (3) 

 The regions insensitive to these four qualities of sensations, both 

 immediately after the section of the nerve and during the period 

 of returning sensibility, were approximately, but by no means 

 exactly, the same. (4) On the whole, the return of sensitivity 

 tended to begin at the outside of the affected area and to progress 

 toward the center, although decided irregularities in this course 

 appeared. (5) In general, hypoesthesia preceded normal sensi- 

 tivity, periods of hyperesthesia, however, being noted for pain and 

 for cold. (6) The observations up to the present time indicate 

 that the return to normal sensitivity will not be simultaneous in 

 the cases of the four sense qualities and that the return in the case 

 of temperature sensations is the more rapid. 



42 (859) 



The alleged discharge of the internal secretion of the pancreas 



into the lymph. 



By A. J. Carlson and F. M. Drennan. 



[From the Hull Physiological Laboratory of the University of Chicago.] 

 In 1898 Biedel 1 reported a "new form of experimental diabetes" 

 by ligation of the thoracic duct and by establishing a fistula of 

 the thoracic duct. These results were interpreted as proving that 

 the internal secretion of the pancreas reaches the blood indirectly 

 via the lymph of the thoracic duct, and led to attempts to modify 

 or control diabetes by treatment with lymph from the thoracic 



1 BeidI, Centralb. f. Physiol., XII, p. 624. 



