Hematin and the Malarial Paroxysm. 8i 



NaHC0 3 ) intravenously in corresponding volumes, and five rabbits 

 were used as controls for accidental temperature fluctuations. 

 The maximum rises in temperature for the individual hematin 

 animals were, 3.5, 2.4, 1.8, 1.8, 1.7, 1.7, 1.5, 1.3, 1.2, 0.8, 0.7, and 

 0.6 degrees Fahrenheit. There was no relation between the dosage 

 and either the temperature rise or the general course of the tem- 

 perature curve. For example, the highest and lowest rise from 

 the initial temperature, 3.5 and 0.6 degrees Fahrenheit, were 

 obtained by nearly the same dosage, 0.013 g. and 0.016 g. per kilo 

 body weight respectively. For animals receiving the solvent alone 

 the maximum rises were, 2.5, 2.2, 1.7, 1.5, 1.2, 1.2, 1.0, and 0.4. 

 The greatest temperature variations in the controls were from 

 — 0.8 to + 1.0 of the initial temperature in Fahrenheit degrees. 

 A composite curve of the variations in temperature of the animals 

 of each series is given. The initial temperature before inoculation 

 is taken as point of origin. 



Curve I. 1 cm. abscissa = 1 hour. 1 cm. ordinate = 1 degree Fahrenheit. 

 Upper full line represents the composite curve of the temperature variations in the 

 hematin animals. Middle dotted line is the composite curve of the solvent animals. 

 Lower full line is the composite temperature curve of the control animals. j 



After intravenous injection of hematin solution in rabbits there 

 is no resemblance in either temperature curve or in other respects 

 to the malarial paroxysm in man. Both the solvent and the 

 hematin solution cause an elevation of temperature in rabbits. 

 There is no significant difference between the temperature curve of 

 the hematin animals and that of the solvent animals. 



Large volumes of the hematin solution, 30 c.c. to 40 c.c. that 

 is over 0.04 g. per kilo body weight, kill rabbits almost imme- 

 diately. Death is caused by intravascular precipitation of hema- 

 tin with consequent embolism of the smaller vessels. The heart 

 blood of animals autopsied immediately after death contains 

 masses of granular hematin. The lungs are brown and their capil- 

 laries plugged with masses of granular hematin. If the animals 



