Pulmonary Reaction to B. pyocyaneus. 



97 



56 (873) 



The depressive action of magnesium sulphate and sodium oxalate 

 and the rapid antagonistic action of calcium. 



By F. L. Gates and S. J. Meltzer. 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute.] 



A. At the October meeting we reported that the effect of a 

 combination of ineffective doses of magnesium sulphate and sodium 

 oxalate is equal to that of an effective dose of magnesium sulphate 

 alone, except that the anesthetic effect due to the combination 

 of the two salts is of greater duration. Each of these two rabbits 

 received about two hours ago 0.8 gm. magnesium sulphate and 0.2 

 gm. sodium oxalate per kilo body weight, subcutaneously. You 

 see, they are still deeply anesthetized and paralyzed. Of the other 

 two rabbits one received 0.8 gm. magnesium sulphate and the other 

 0.2 gm. sodium oxalate per kilo body weight subcutaneously. You 

 see they behave practically normally. 



B. Now each of the anesthetized animals receives through the 

 ear vein, about 8 c.c. of a 2.5 per cent, solution of calcium chloride. 

 You see that the respiration becomes deeper and more rapid almost 

 immediately and within a minute of the beginning of the injection 

 they turn over and sit up. 



57 (874) 



The pulmonary reaction to B. pyocyaneus. 

 By Martha Wollstein and S. J. Meltzer. 



[From the Laboratory of the Rockefeller Institute.} 



Intra-bronchial insufflation of broth cultures of B. pyocyaneus 

 in doses of 10-15 c - c - were more fatal than any other organism thus 

 far used, except B. prodigiosus. 



The lesion produced was that of a lobular pneumonia with 

 intra-alveolar hemorrhage and fibrinous pleurisy. The bacilli were 

 recovered from the heart's blood and from the lungs. 



