102 



Scientific Proceedings (57). 



ether. Experiments now in progress seem to indicate that the 

 acetone extract of egg yolk possesses in some degree at least the 

 same power to induce new growth in rats whose growth has become 

 suspended after long feeding with diets of purified food substances. 



62 (879) 



The experimental production of hyaline casts by injections of 



magnesium salts. 



By F. L. Gates (by invitation). 



[From the Department of Physiology and Pharmacology of the 

 Rockefeller Institute for Medical Research.] 



In view of the urinary findings after magnesium-ether anes- 

 thesia in human cases, just reported to you by Dr. Peck, Dr. 

 Meltzer suggested that we try to produce hyaline casts in animals 

 by injections of magnesium salts. 



We have used rabbits, monkeys, and dogs, but the results to 

 be reported tonight relate only to experiments on dogs. Epsom 

 salt in sublethal doses, with and without ether by insufflation, 

 was given to dogs intramuscularly and intravenously. In all 

 cases many hyaline casts appeared. They were most abundant 

 from 3 to 6 hours after the injection and disappeared in 24 or at 

 most 48 hours. No epithelial or granular casts were found and 

 no measurable albuminuria occurred. Ether alone did not pro- 

 duce casts and ether and magnesium produced no more than 

 magnesium alone. In one experiment, magnesium chloride gave 

 the same results as the sulphate. 



Our essential point is that hyaline casts in large numbers can 

 be produced in dogs at will by injections of magnesium salts. 

 Epithelial and granular casts and albuminuria are not present and 

 the appearance of the hyaline casts is only temporary. 



