Uric Acid Concentration of Blood. hi 



suckle at least 30 c.c. at ten feedings. This is an amount that 

 the breast does not secrete, at least until the fourth day. Feeding 

 the newborn infants for the first three days, in addition to the 

 breast secretion, a formula of about the same composition as 

 colostrum would appear to be a logical proceeding not only to 

 fulfill the energy requirement but also to supply the water lost. 



Even after the breasts are secreting a considerable quantity of 

 milk it would seem to be rational to feed these babies as often as 

 every two or two and one half hours during the day or eight or 

 nine feedings in all. 



68 (885) 



The influence of phenylquinolin carbonic acid (atophan) and of 

 radium emanation upon the uric acid concentration of 

 the blood. 



By Morris S. Fine and Arthur F. Chace. 



[From the Laboratory of Pathological Chemistry and the Department 

 of Medicine, New York Post-Graduate Medical School and 

 Hospital.] 



The prompt and marked increase in the uric acid output 

 following the administration of 2-phenylquinolin-4-carbonic acid 

 (atophan) has been repeatedly demonstrated. More recently, 

 Folin and Lyman 1 reported a concomitant diminution in the uric 

 acid concentration of the blood, which suggested an increased 

 renal permeability as an important factor in the physiological 

 action of atophan. 



In the course of our studies with atophan, begun more than a 

 year ago, we have endeavored to ascertain, (1) the promptness 

 with which the decrease in blood uric acid is brought about; (2) 

 the minimum to which it can be reduced ; and (3) the rapidity with 

 which the initial concentration is regained after the administration 

 of atophan has ceased. 



We have observed a marked decrease in the uric acid concen- 

 tration of the blood after a two day period with atophan; and are 

 attempting to determine more exactly the speed of this reaction. 



1 Folin and Lyman, Jour. Pharm. and Expt. Ther., IV, p. 539, 1913. 



