Colloidal Nitrogen in Diabetes. 



113 



2. The hyaline phase in which the globular component is 

 localized in a small area of the extremely hyaline cytoplasm. 



3. The fine pseudopodial phase which is characterized by 

 the protrusion of fine long motionless protoplasmic processes. 



4. The ciliated phase of the white blood cell shows numerous 

 beating cilium-like processes. 



5. The flagellated phase is distinguished by the presence of 

 numerous long protoplasmic processes which exhibit the rapid 

 undulatory movement characteristic of flagella. 



Notable redistribution phenomena have been observed in 

 erythrocytes of both warm- and cold-blooded vertebrates as well 

 as the formation of either cilium-like or flagellum-like processes. 

 White blood cells or erythrocytes which have numerous rapidly 

 moving protoplasmic processes may be actually free-swimming. 



Similar structural transformations have been observed in 

 myelocytes, "pyrrhol" cells, and in cells from inflammatory 

 exudates. 



The role of structural transformations of white blood cells in 

 phagocytosis has been investigated with interesting results. 



70 (887) 



Colloidal nitrogen in diabetes. 



By George B. Wallace. 



[From the Laboratory of Pharmacology, University and Bellevue 

 Hospital Medical College.] 



The so-called colloidal nitrogen fraction of the urine has 

 normally a fairly constant relationship to the total nitrogen, 

 forming from 1 to 4.5 per cent, of the latter. In a number of 

 pathological conditions, the percentage may be greatly increased, 

 rising in some instances to 35 per cent. In a study of this subject 

 by Pribram and collaborators, it was found that in severe diabetes, 

 among other diseases, the percentage of colloidal nitrogen was 

 especially high. Pribram interprets this as an evidence of ab- 

 normal or lessened liver function and associates it with the occur- 

 rence of diabetic coma. 



I have determined the colloidal nitrogen fraction in two cases 



