126 



Scientific Proceedings (58). 



Abstracts of Communications, Pacific Coast Branch. 



Fifth Meeting. 



San Francisco, California, April g, IQ14. 



77 (894) 



The pressor compounds of the pituitary gland. 



By Albert C. Crawford and Zeno Ostenberg. 



[From the Division of Pharmacology, Stanford University Medical 



School.] 



The pituitary gland of cattle contains several pressor principles, 

 one or more of which dialyze and at least one which does not dialyse 

 through parchment paper. The non-dialyzable compound or 

 compounds can be purified by lead subacetate and the filtrate, 

 freed from lead, does not give the biuret reaction, at least in dilu- 

 tions which give a pressor reaction, but yields a white benzoate 

 (Baumann-Schotten method). The depressor principle readily 

 dialyzes, but apparently depressor compounds form on long 

 standing of the non-dialyzable portion. 



78 (895) 



Note on the action of epinephrin on the guinea-pig uterus. 



By E. Barbara Will and Albert C. Crawford. 



[From the Division of Pharmacology, Stanford University Medical 



School.] 



On the isolated horn of the non-pregnant guinea-pig uterus 

 suspended in oxygenated Locke's solution (Dale's modification), 

 epinephrin (0.9 mg. in 500 c.c. at 41 0 C.) produced relaxation. 

 Longitudinal strips also relaxed. Circular strips gave slight 

 imperfect contractions. Direct inspection of the intact uterus 

 showed that the intravenous injection of epinephrin produced 

 blanching with contraction of the circular fibers. Diminution in 

 the diameter of the horn and elongation was observed. This 

 would suggest that the difference in action of epinephrin on the 



