132 



Scientific Proceedings (59). 



added, however, that tests on several cases of hemophilia have 

 shown that the blood vessels are not affected in this disease, and 

 that the blood does not permeate the vessel wall when subjected 

 to this amount of increased pressure. 



81 (898) 



A note on the retention in the blood of uric acid and creatinine 

 in the uremic type of nephritis. 1 



By V. C. Myers and M. S. Fine. 



[From the Laboratory of Pathological Chemistry, New York Post- 

 Graduate Medical School and Hospital.] 



In two cases of nephritis of the uremic type with high non- 

 protein nitrogen and urea, very high figures for both uric acid and 

 creatinine have been observed. The increase in the concentra- 

 tion of these substances is best shown in tabular form. The 

 figures are in mgm. per 100 c.c. of blood. 



Case. 



Date. 



Non-protein 

 N. 



Urea 

 N. 



Uric Acid. 



Creatinine. 



Creatine and 

 Creatinine. 



I 



Mar. 7 



2p2 



200 



10.5 















II. 0 



9-0 



iS-o 





Mar. 9 



207 



182 



1 1.4 



16.6 





2 



May 4 







6.1 









May 7 



155 



120 



8.0 



10. 0 



16.0 





May 13 a.m. 



I84 



140 



13-7 



13-9 



17.2 





May 13 p.m. 



226 



170 



14.0 



14.7 



27.8 



The progressive increase in the various constituents as the 

 condition approaches a fatal termination is well shown in Case 2. 

 Attention is called to the possible etiological importance of the 

 retention of creatinine on account of its containing the toxic 

 guanidine group, also to the probable diagnostic and prognostic 

 value of the determinations for uric acid and creatinine in this con- 



1 After the title of our communication was submitted, papers appeared by O. 

 Neubauer, Munch, med. Wochenschr., (Apr. 21) 1914; LXI, p. 857, and by Folin 

 and Denis, Journ. Biol. Chem., (May) 1914, XVII, p. 487, reporting somewhat 

 similar observations. Neubauer records one case of uremia with marked retention 

 of creatinine in the blood, while Folin and Denis present ten cases of uremia with 

 analyses of uric acid, creatinine together with the other nitrogenous constituents. 



