136 



Scientific Proceedings (59). 



exactly duplicates in all essential features the urinary findings in 

 the later stages of severe types of diabetes mellitus. The dextrose 

 to nitrogen ratio is approximately 3.6 upon a carbohydrate free 

 diet. Glucose given at this time was quantitatively recovered. 

 In spite of doses of sodium bicarbonate ranging from 20 to 30 

 grams per day the ammonia output rose to over four grams per 

 day, representing 27 per cent, of the total nitrogen at its highest 

 level. Oxy-butyric acid, diacetic acid, and acetone were elimi- 

 nated in large amounts. When large quantities of glucose were 

 given the urine picture returned to normal almost at once, and 

 the diabetes completely ceased when phlorhizin administration 

 was stopped, the patient rapidly returning to normal condition. 

 Considering the severity of the treatment the patients stand it 

 surprisingly well. They lose weight, but the general condition 

 does not at all duplicate the later stages of diabetes mellitus. 

 The findings in this case will be reported in detail elsewhere. 



84 (901) 



A study of further generations of mammals from ancestors 

 treated with alcohol. 



By Charles R. Stockard. 



[From the Department of Anatomy, Cornell Medical School, New 



York City.] 



Experiments now in progress for almost four years have 

 demonstrated the fact that the germ cells of male guinea-pigs can 

 be so injured by allowing the animals to inhale the fumes of 

 alcohol that they give rise to defective offspring although mated 

 with vigorous untreated females. 1 



In the present communication I wish to emphasize the fact 

 that the effect of this injury of the germ cells is not only shown by 

 the immediate offspring of alcoholized animals but is conveyed 

 through their descendants for at least three generations. 



The offspring from the treated guinea-pigs which reach ma- 



1 Archivf. Entw.-Mech., XXXV. 1912; Archives of Int. Med., X, 1912; American 

 Nat., XLVII, 1913. 



