142 



Scientific Proceedings (59). 



mm. distant from beating embryonal heart tissue, does not kill 

 it in three hours, and does not stop the growth of connective tissue 

 cells. The same exposure, however, does prevent the growth of 

 Jensen rat sarcoma, and inhibits but does not wholly prevent the 

 growth of the Flexner rat carcinoma. Observations such as these 

 show the danger of generalizing too freely from a limited number 

 of expeiiments. 



86 (903) 



Note on the effect of animal extracts upon the secretion of the 



pancreas. 



By Isaac Ott, M.D., and John C. Scott, M.D. 



[From the Laboratory of the Medico- Chirurgical College of 

 Philadelphia.] 



Our experiments were made upon etherized cats who were 

 killed before regaining consciousness. A Bernard cannula was 

 inserted into the pancreatic duct inside the lumen of the intestine. 

 The biliary duct was previously ligated. We then injected secretin 

 solution into the jugular, as no secretion was noted before its 

 injection. We then counted, after the injection of secretin, the 

 number of drops falling every 5 minutes for three periods. Then 

 we injected the same amount of secretin plus a watery solution of 

 one of the dried glands. Then we counted for three periods the 

 number of drops every 5 minutes. Finally we again injected the 

 same amount of secretin solution and again noted the number of 

 drops every 5 minutes for three periods. If in the second period 

 we obtained a marked increase over or decrease below the first 

 period and third period, we inferred that the animal extract had 

 some action. We obtained the following results. We also have 

 inserted their effects upon the volume of the gland for comparison. 



Animal Extracts. Pancreatic Volume. Pancreatic Secretion. 



Parathyroid .increases increases 



Secretin increases increases 



Mammary. . .increases increases 



Infundibulin. decreases for 3 minutes then increases. . .decreases (Pemberton & Sweet) 

 Adrenalin. . . decreases for 3§ minutes then increases. . decreases (Pemberton & Sweet) 

 Pinea increases increases 



