i6o 



Scientific Proceedings (60). 



in very small amount. The urine of the adult animals invariably 

 contained acetone. 



The present series of forty-eight animals shows the same differ- 

 ences in the total output of urine and in the composition of the 

 urine as has been above referred to. 



In addition, these animals of different ages show certain other 

 characteristics which are apparently dependent upon the age of 

 the animal. 



1. Ten of the animals were puppies varying in age from four to 

 eight and a half months. Only one of these animals developed a 

 glycosuria within the first twenty-four hours following the initial 

 injection of 6.7 mgs. of uranium. The percentage of glucose in the 

 urine of this animal was 0.103 P er cent. 



2. In none of the puppies was acetone present in the urine 

 following the first injection of uranium. 



3. Following the second injection of uranium all of the puppies 

 developed a glycosuria. The percentage of glucose varied from 

 0.35-1. 1 per cent. 



4. Following the second injection of uranium only two of the 

 puppies showed the presence of acetone in the urine. The amount 

 of acetone was exceedingly small. 



The full-grown animals and old animals have shown the fol- 

 lowing differences in their response to the same quantity of uranium 

 per kilogram that was received by the puppies. 



1. With three exceptions, the remaining thirty-eight adult 

 animals all developed a glycosuria within twenty-four hours 

 following the first injection of 6.7 mgs. of uranium. The percen- 

 tage of glucose varied from 0.18-1.61 per cent. The three highest 

 percentages of glucose — 1.61, 1.59 and 1.24 per cent were obtained 

 in old aaimals. 



2. Following the second injection of uranium all of the full 

 grown animals became glycosuric. The percentage of glucose 

 varied from a minimum of 1.47 per cent to a maximum of 2.86 

 per cent. 



3. Acetone was present in the urine of all of the full grown 

 animals following the first injection of uranium excepting the 

 three animals that failed to develop a glycosuria following the first 

 uranium injection. 



