Scientific Proceedings (60). 



bile capillaries or in that zone of the cell which immediately 

 surrounds the capillaries. 



In the kidneys of these animals the fat first appears in the 

 loops of Henle. The fat is most pronounced in the ascending limb 

 of Henle's loop. 



In puppies and young dogs the fat is in small amount and 

 appears in the form of minute granules in the epithelium lining 

 these tubules. In adult animals and especially in old animals the 

 fat is very greatly increased in amount and is seen in the form of 

 large granules which may coalesce to form masses which serve to 

 outline the course of the tubule. 



There is apparently an association between the amount of fat 

 found in the liver and kidney of animals of different ages with the 

 amount of glucose present in the urine. The puppies and young 

 animals which show a low percentage of glucose in the urine show 

 a small amount of fat in the liver and kidney. 



The full-grown animals and old animals which have shown an 

 earlier appearance of glucose in the urine and a percentage of 

 glucose which has been much higher than has been found in the 

 puppies also show fatty changes in the liver and kidney of much 

 greater severity. 



100 (917) 



Variations in resistance of red blood cells in sheep. 



By R. Ottenberg and J. G. Hopkins. 



[From the Department of Bacteriology, College of Physicians and 



Surgeons, N. Y.] 



In the course of complement fixation work we have noticed 

 that the specimens of blood cells obtained from different sheep 

 under exactly similar conditions occasionally show marked dif- 

 ferences in their susceptibility to laking by specific lytic serum. 

 When this was first noticed we were using two sheep as a source of 

 blood, and as the sheep whose cells were more highly resistant was 

 one which had been bled repeatedly and profusely it was natural 

 to attribute the increased resistance of the cells to this. 



We determined to investigate this question and also to find 

 out whether the increased resistance was a specific resistance to 



