i;o 



Scientific Proceedings (60). 



one or two intermissions). Single doses did not exceed 3 mg. 

 subcutaneously and 2 mg. intravenously. 



Macroscopical changes found in other organs. 



Stomach : ecchymoses in three dogs. Small intestines : marked 

 congestion and hemorrhagic patches in two. Large intestines: 

 slight hyperaemia in one. The appendix was atrophic and con- 

 stricted in one. Lungs: Congestion of lower left lobe in one. 

 Head of pancreas was found to be congested in two. Spleen was 

 firm to the touch in one. Thyroidea, adrenals and thymus did 

 not appear to be enlarged in any of the dogs. 



The findings of duodenal lesions in each and in every dog could 

 not be explained by mere coincidence. 



In two dogs, used as controls, who were injected for about one 

 week with thyroid extract, no lesions were found in the duodenum, 

 but only in the stomach : erosion and ulcerations. 



In one dog from whom the right lobe of the thyroid was ex- 

 tirpated and killed seven days later, two distinct soft ulcers were 

 found at the first portion of the duodenum and no lesions were 

 seen in the stomach. 



I have also succeeded in producing gastric erosions and ulcers 

 in rabbits by extirpation of one or both suprarenals. Autopsy 

 was performed not before the seventh day after removal of the 

 glands and not later than on the thirteenth except in two, who 

 died. 



Findings in five rabbits after extirpation of left adrenal. 



Erosions and ulcers at the pylorus in three, erosion at the 

 pylorus and ulcer in first portion of duodenum in one, and no 

 lesions in one. In the case of double ulcer the right adrenal was 

 found to be nearly twice as large as normally ; except new glandular 

 tissue appeared at the site of the extirpated adrenal. In the case 

 with negative findings fragments of new tissue were seen at the 

 site of the extirpated gland and the right adrenal was found to be 

 somewhat larger. 



Findings after extirpation of right adrenal. 

 Erosions at the lesser curvature, proximal to the cardia in three 

 rabbits, a round ulcer at the posterior wall of the stomach, near 



