14 



Scientific Proceedings (109). 



If the animals are fed on the posterior lobe of hypophysis 

 growth is not only not stimulated, but even greatly retarded 

 as may be seen from two live animals, a control and a posterior 

 lobe fed animal, both descendants of the same female and of the 

 same age. 



Feeding of anterior lobe causes (1) a very marked acceleration 

 of growth and (2) a continuation of growth beyond the specific 

 size of the species resulting thus in hypophyseal gigantism. 

 Feeding of posterior lobe has neither of these two effects, but even 

 retards growth. 



Since in these experiments the hypophysis was fed without 

 the addition of normal food and in large doses, one may think 

 that the results were caused not by the action of a specific sub- 

 stance contained in the hypophysis but merely by the greater 

 food value of the gland. Part of the acceleration of growth may 

 have been actually due to merely quantitative differences in the 

 food substances; but it should be pointed out that it is impossible 

 to renew growth by feeding even large quantities of normal food 

 after growth has come practically to a standstill. As regards 

 the continuation of growth beyond the normal size of the species, 

 it is obvious that the alteration of this specific character of growth 

 cannot be due to an increased amount of food and it seems, there- 

 fore, that at a stage where growth ceases or is greatly diminished 

 under normal conditions, cell proliferation can be actually enforced 

 by the specific growth-promoting substances contained in the 

 anterior lobe of the hypophysis. 



6 (1588) 



Observations on bacterial metabolism. 



By J. Howard Mueller. 



[From the Department of Bacteriology, College of Physicians and 

 Surgeons, New York City.] 



In the course of an investigation of the cultural requirements 

 of certain of the pathogenic bacteria, a substance which occurs in 

 meat infusion, and also in some of the proteins has been found to 

 be essential for the growth of the streptococcus, and for certain 



