24 



Scientific Proceedings (109). 



anemia on the liver of dogs. To produce this anemia, Eck fistulas 

 were made. From five to seven weeks later the abdomen of each 

 dog was reopened, and temporary ligatures placed about the 

 hepatic artery and portal vein. The ligatures were kept in place 

 for from three to twelve hours. The animals were killed from two 

 to six days later. 



During the period of ligation, the dogs showed no toxic symp- 

 toms. After the release of the ligatures they were in every way 

 apparently normal till the date of the autopsy. The following is 

 a summary of the histological findings : 



(a) Three hour anemias: No thrombosis. No necrosis or 

 atrophy of the hepatic parenchyma. Moderate degree of fatty 

 degeneration, mainly confined to the central third of the lobule. 



(b) Twelve hour anemias: No thrombosis. No necrosis. 

 Marked fatty degeneration of the central half of the lobule, 

 with slight atrophy of the parenchyma immediately surrounding 

 the central vein. 



From these findings we conclude that the almost total anemia 

 produced by temporary ligation of the hepatic artery and portal 

 vein in Eck fistula dogs, for periods as long as twelve hours, 

 does not cause necrosis of the hepatic parenchyma. 



This power of the hepatic cells to resist local anemia probably 

 accounts in large measure for the infrequency of infarcts in the 

 liver, which infrequency is usually attributed solely to the presence 

 of the double hepatic circulation. 



Experiments extending over longer periods of time will be 

 reported later. 



14 (1596) 



An attempt to produce hemochromatosis experimentally. 



By Loren R. Chandler (by invitation). 



[From the Laboratory of Experimental Pathology, Stanford University, 



California.] 



The hypothesis is suggested by MacCallum 1 that hemo- 

 chromatosis may possibly be due to iron retention, secondary to 

 decreased excretion of waste iron by the colon. We have at- 

 tempted to test this hypothesis by a surgical removal of the 

 colon of dogs. 



1 MacCallum, "Text-Book of Pathology," 1916, p. 112. 



