Memory and Behavior of Albino Rats. 27 



the leucocytes which, as pus cells, have been shown to contain a 

 considerably greater amount of cholesterol than the normal 

 leucocytes. 



Analysis of empyema exudates showed that the greater part 

 of the cholesterol is contained in the cellular portion of the exudate. 

 The fluid portion of exudates contains even less cholesterol than 

 normal serum or exudates in the pleural cavity which contain 

 relatively few cells. 



Since the activity of the leucocytes is an important factor in 

 the resistance to and recovery from pneumonia, the association of 

 the variation of the cholesterol with the activity of the leucocytes 

 seems to indicate the role which cholesterol plays on leaving the 

 blood serum in acute infections. Carried by the leucocytes 

 to the site of the active inflammatory process, cholesterol is avail- 

 able for the neutralization of bacterial toxins and poisons arising 

 from the disintegration of tissue and exudate in the process of 

 resolution of the pneumonic exudate. 



16 (1598) 



Effect of antipyretics on memory and behavior of albino rats. 

 By D. I. Macht and Wm. Bloom. 



[From the Pharmacological Laboratory, Johns Hopkins University.] 



Studies were made by the authors on the behavior of white 

 rats in Watson's circular maze. All the drugs were administered 

 by subcutaneous or intraperitoneal injections. The following 

 drugs were studied; acetanilid, acetphenetidin, antipyrin, pyrami- 

 don, sodium salicylate, phenyl salicylate or salol and quinine 

 sulphate. 



Acetanilid was administered in doses from 1 to 5 milligrams 

 and was found to produce depression. Phenacetin also produced 

 depression but not to the same extent. Salol in small doses pro- 

 duced no effect ; larger doses (5 milligrams) caused slight depression. 

 Sodium salicylate caused slight depression. Quinine produced 

 depression when administered in doses from 2 l / 2 to 5 milligrams. 

 Antipyrin was found to be most depressing of all even when 

 the doses were 2 milligrams. Pyramidon was also depressing but 

 not to the same extent. 



