28 



Scientific Proceedings (109). 



The following combinations were studied: acetanilid plus 

 sodium bicarbonate, acetanilid plus phenacetin, sodium salicylate 

 plus salol, phenacetin plus pyramidon, acetanilid plus pyramidon 

 and salol plus acetanilid. 



It was found that acetanilid plus phenacetin and salol plus 

 sodium salicylate combinations gave a summation effect, whereas 

 phenacetin plus pyramidon and acetanilid plus pyramidon ex- 

 hibited synergistic phenomena. The most striking combinations 

 were acetanilid plus bicarbonate of soda and acetanilid plus salol. 

 In the case of each of these combinations acetanilid was not as 

 depressent as when given alone. 



The effect of opiates on the behavior of rats has already been 

 published. Investigations are in the process of completion con- 

 cerning the effect of the following drugs on the memory and be- 

 havior of rats in the maze: alcohol, caffeine and nicotine; cocaine 

 and its decomposition products; digitaloid drugs and some others. 

 Complete data concerning the antipyretics will appear in the 

 Journal of Pharmacology and Experimental Therapeutics. 



17 (1599) 

 Amicronucleate infusoria. 



By LORANDE LOSS WOODRUFF. 



[From the Osborn Zoological Laboratory, Yale University.] 



It has generally been accepted that the dimorphic condition 

 of the nucleus (macronucleus and micronucleus) is a diagnostic 

 character of typical Infusoria, and, aside from a few primitive or 

 aberrant species, the only apparent exceptions have revealed 

 the micronucleus (or micronuclei) within the macronuclear 

 membrane during vegetative stages. Recently, however, Dr. 

 Dawson, working in this laboratory, described a race of Oxytricha 

 hymenostoma Stokes which throughout several years of pedigree 

 culture showed no indication of a morphological micronucleus. 1 



During the past year, the isolation for certain experiments 

 of 14 "wild" lines representing 6 species of hypotrichous Ciliates 

 revealed 7 lines (4 species) with micronuclei and 7 lines (2 species) 



1 J. A. Dawson, "An Experimental Study of an Amicronucleate Oxytricha," 

 Journ. Exper. Zoology, 1919, xxix, 473; 1920, xxx, 129. 



