Anaphylaxis in Lower Monkeys. 



63 



two or three times, but immediately gets up again and keeps him- 

 self upright by holding onto the cage. Very distinctly in distress; 

 gradual recovery within 10 to 15 minutes. 



August 13, skin reaction negative, 7 ex., 1-5 egg white intra- 

 venously injected; after 3 minutes is distinctly distressed, respira- 

 tion very fast; face suddenly very red; legs weak; falls to the 

 ground, but is immediately up again, clinging to the cage; returns 

 to normal after 10 minutes. 



Monkey IV, Macacus Rhesus. — Young female mate to pre- 

 ceding monkey. This monkey was treated exactly like the pre- 

 ceding. Titrations, skin reactions and injections were run parallel 

 to Monkey III. At no time did we get any indication of positive 

 skin reaction, nor did we, in four separate titrations carried out 

 between May 24 and August 13, ever find the slightest trace of 

 antibody formation. We never obtained, after injection of egg 

 white, reactions comparable to those obtained in Monkey III, 

 nor anything else that could be interpreted as anaphylactic shock. 



Monkey V, Brown Ringtail Monkey. — The intention was to 

 prepare this monkey by a number of injections before tests were 

 done on him. 



October 15, 10 c.c, 1-5 egg white, intravenously 

 October 18, " " " " 

 October 20, 6 " " 11 



October 26, bled and titrated; no, antibody; slight trace of 

 antigen in dilutions up to 1-10 of the monkey serum. 



October 30, bled and titrated with all necessary controls; no 

 antibody and no antigen in monkey serum, although readings 

 were made up to as long as 48 hours in the ice-chest. 



November 5, skin reaction negative. Titration shows no 

 antibody and no antigen; 14 c.c, 1-5 egg white injected, intra- 

 venously. Within a few minutes shivering and a general tremor 

 of body and limbs; monkey lies down and is weak, very apparently 

 sick; will not eat, and seems to prefer lying on his side when left 

 alone. There are none of the ordinary signs associated in our 

 minds with anaphylaxis, but for 4 to 5 hours after the injection, 

 the monkey allows himself to be handled without much protest, 

 remains lying on his side, and acts generally weak and sick; at 

 the end of 5 hours, he gradually begins to improve, and eats a 

 little bread, and from that time gradually recovers. 



