Anaphylaxis in Lower Monkeys. 



65 



regard as mildly analogous to human serum sickness, with definite 

 redness and swelling, and some edema of the lower part of the 

 face and lips, lasting about 2 hours. On May 5, 27 days after the 

 third injection, again with small amounts of antibody present in 

 the serum, this same monkey showed nothing but watering of the 

 eyes, and extensive itching of the nose and eyes, with shivering 

 and, otherwise, reactions that could be regarded as slight ana- 

 phylactic symptoms if they were observed in human beings. 



In Monkey III, treated with egg white, 25 days after the second 

 injection, with slight amounts of antibody present in the serum, 

 a definite reaction was obtained by reinjection of 10 c.c, 1-5 egg 

 white intravenously, described in the text under this monkey, 

 unmistakably as a severe reaction of some kind, coming on within 

 2 minutes, and completely over in 5 minutes. This same monkey 

 15 days after the third injection, and 17 days after the fourth 

 injection, always with a small amount of antibody in his serum, 

 manifested similar reactions on each occasion. In Monkey IV 

 and Monkey V, antibodies were never found and no symptoms 

 that could, in any way, be spoken of as anaphylactic, either in 

 nature or in time of occurrence, were observed. 



We believe that we are justified in concluding that anaphylaxis 

 is very difficult to obtain in the lower monkeys, probably cannot 

 be obtained by a single preparatory injection, but that occasionally 

 definite mild anaphylactic reactions can be obtained in these 

 animals, in One case simulating some of the symptoms associated 

 in human beings with serum sickness (Monkey II), and in our 

 series this occurred only in monkeys in which small amounts of 

 antibody could be demonstrated. 



Why antigen should disappear with relative speed, and no 

 antibodies appear in some of these monkeys, may possibly be 

 explained by the fact that in the last monkey, we observed that, 

 within a few hours, the egg white had passed through the kidney 

 into the urine with remarkable speed. 



To some extent our results with the monkeys indicate analogy 

 to conditions in human beings as found by McKensie in his studies 

 upon the parallelism between the antibody curve and serum sick- 

 ness, but at the same time they show that human beings are con- 

 siderably better anbitody producers than are the monkeys, and 



