74 



Scientific Proceedings (iio). 



amined for the presence of mercury by the method of Elliott. 

 Following two days of normal observations, the animals were 

 given 4 mgs. per kilogram of mercuric chloride by stomach tube. 

 Prior to administering the mercury the dogs were partially 

 narcotized by a subcutaneous injection of 0.25 c.c. of a 4 per cent, 

 solution of morphine sulphate per kilogram. Such a procedure 

 prevents the vomiting of the mercury. After the introduction of 

 the poison the animals were studied by the methods just outlined. 

 At definite periods during the course of the intoxication, 6, 12 and 

 24 hours, the animals were killed without the use of an anesthetic 

 and autopsied. The liver and kidney were studied histologically. 



The course of two experiments that are representative of the 

 condition of the fourteen animals in the very early stages of poison- 

 ing by mercuric chloride are outlined in Table I. At the com- 



TABLE I. 



Elimination of Phenolsulphonephthalein in Acute Mercuric 

 Chloride Intoxications 



Number 

 of Ex- 

 peri 

 ment. 



Duration of Ex- 

 periment. 



Mercuric 

 Chloride 

 Mgs. per 

 Kg. 



Urine in 

 24 Hours. 



Albumin 

 and Casts. 



Phtha- 

 lein per 

 Cent. 



R. 

 P- 

 H. 



Blood 

 Urea 

 Mgs. 

 per 100 



Cc. 



Mer- 

 cury in 

 Urine. 



10 



Normal 



0 



368 C.C. 



0 



56 



8.4 



18 



O 





Observation 



















Normal 



















Observation 



0 



478 C.C 



0 



53 



8.4 



20 



0 





6 hours 



















Animal 



4 rngs- 



57i c.c. 



Trace 



68 



8.1 



12 



0 





killed 



per kg. 





no Casts 











13 



Normal 



















Observation 



0 



281 C.C. 



0 



72 



8.3 



22 



0 





Normal 



















Observation 



0 



310 C.C. 



0 



70 



8-3 



24 



0 





12 hours 



4 mgs. 



















per kg. 



365 c.c. 



0 



78 



8-3 



17 



Trace 





24 hours; 



















animal 





491 C.C. 



Trace 



74 



8.1 



17 



Trace 





killed 

















mencement of each experiment normal observations are recorded 

 for two days prior to the commencement of the intoxication. A 

 study of this normal record shows the urine to be free from both 

 albumin and casts. The total output of urine in a twenty-four 

 hour period has varied with the fourteen animals from 281 c.c. to 

 576 c.c. The elimination of phenolsulphonephthalein in a two 



