Acute Mercuric Chloride intoxication. 75 



hour period has ranged from 53 to 84 per cent. Blood urea deter- 

 minations have varied from 18 to 27 mgs. per 100 c.c. of blood. 

 The alkali reserve determinations in all of the animals have only 

 shown a variation between 8.3 to 8.4. 



The animal of Experiment 10, six hours after receiving the 

 mercury showed a distinct increase in the output of urine. The 

 urine in this six hour interval amounted to 571 c.c, as opposed to 

 the normal maximum output for a twenty-four hour period of 

 478 c.c. At this early period a trace of albumin appeared in the 

 urine. Casts were not present. Associated with the develop- 

 ment of the albuminuria the reserve alkali of the blood was reduced 

 from the normal of 8.4 to 8.1. The elimination of phenolsulpho- 

 nephthalein was increased from the normal maximum output of 

 56 per cent, to 68 per cent. The blood urea showed a decrease 

 from the normal maximum of 20 mgs. per 100 c.c. of blood to 12 

 mgs. The urine did not show the presence of mercury. 



The animal of Experiment 13, Table I, received the same 

 amount of mercury per kilogram as the animal of Experiment 10. 

 The duration of the experiment was twenty-four hours. The 

 course of the intoxication is in general similar to that shown by 

 the previously outlined experiment. Twelve hours after the use 

 of the poison the output of urine gave an increase of 55 c.c. over 

 the normal elimination for the preceding twenty-four hours. 

 By the end of the first twenty-four hours of the poisoning the 

 animal had formed 856 c.c. of urine as opposed to the maximum 

 output for a twenty-four hour normal period of 310 c.c. At the 

 end of the first twelve hours of the experiment the urine was free 

 from albumin but contained a trace of mercury. The elimination 

 of phenolsulphonephthalein had increased from 70 to 78 per cent. 

 The reserve alkali of the blood remained unchanged. The 

 blood urea was reduced from 22 mgs. per 100 c.c. to 17 mgs. 

 At the end of twenty-four hours of the intoxication the urine 

 contained a trace of albumin. The elimination of phenolsulpho- 

 nephthalein was reduced from 78 per cent, to 74 per cent. The 

 normal elimination of the dye was 72 per cent. The reserve 

 alkali of the blood was reduced from the normal of 8.3 to 8.1. 

 The blood urea remained unchanged, 17 mgs. per kilogram. 



The pathology of the liver and the kindey in these animals 



