n6 



Scientific Proceedings (112). 



C.c. of CO2 Bound 

 as Bi carbonates by 

 100 c.c. of Plasma. 1 



Normal. 



Effect Produced. 



Agent Used. 



58.0 



24.O 



Uranium 



54-0 



30.0 





57-0 



43-0 





57-0 



53-0 





65-0 







58.0 



72.0 





58.0 * 







47.0 



41.0 





56.0 



18.0 





53-o 



25 0 





54-o 







64.0 



64.0 





58.0 



70.0 





50.0 



30.0 



Uranium after double nephrectomy 



54-0 



54-0 





54-0 



54-0 





1 In the table the time relationships are omitted. In some instances, for example 

 in the cyanide experiment, the duration of the poisoning was a few hours. In others 

 the duration was a number of days. 



whose action is confined to the intestinal capillaries, cause no 

 acidosis. Hydrazin, which is not classed as a capillary poison, 

 but which produces changes confined to the liver, and comparable 

 to those seen in phosphorus poisoning, causes no acidosis. Hista- 

 mine, given by subcutaneous injection in repeated and eventually 

 fatal doses caused an increase in alkali reserve, given intravenously 

 to an animal sensitized by ether, it causes acidosis. 



If our conception of the cause of the acidosis from these capil- 

 lary poisons is correct, it should follow that other agents which 

 interfere with the supply of oxygen to the tissues in other ways 

 would also cause acidosis. This is indeed the case. Nitrites, 

 which induce methaemoglobin formation, and cyanides, which 

 prevent the utilization of oxygen by the tissues, bring about a 

 marked acidosis. To show that a depression of the nervous 

 system and respiratory center is not a factor, we have given a 

 dog 2 grams of morphine during a period of 6 hours, with no re- 

 sulting acidosis. A double nephrectomy in itself causes no acid- 

 osis. Uranium given to an animal with both kidneys removed, 

 induces the same degree of acidosis as in an animal with the kidneys 

 intact. Again in poisoning with emetine, with marked effects in 



