202 



Scientific Proceedings (114). 



and a small nodule appeared at the site of the old chancre. Al- 

 though it was known that the animal still harbored spirochetes, 1 

 none could be demonstrated by dark-field examination of material 

 from the nodule and it was excised for histological examination. 

 There was a prompt recurrence and with the growth of the second 

 cutaneous lesion, the left inguinal glands became markedly en- 

 larged and indurated. Again no spirochetes could be demon- 

 strated and the lesion with one of the adjacent glands was excised 

 under ether anesthesia. Histological examination of the cutaneous 

 nodules and gland showed a giowth which presented more the 

 appearance of a neoplasm than of a syphilitic lesion. It was 

 composed for the most part of atypical epithelioid cells undergoing 

 active proliferation and exhibiting marked invasive tendencies. 



Meantime there was a second recurrence and extension of the 

 skin lesion over the mid line at the pubis with enlargement and 

 induration of the right inguinal nodes. A deterioration in the 

 physical condition of the animal was then apparent and progressed 

 very rapidly, culminating in emaciation, weakness, severe anemia, 

 loss of sphincter control with some spasticity of the hind legs and 

 the formation of trophic ulcers about the anus and sheath. On 

 this account, the animal was etherized. 



Post-mortem examination revealed a widespread distribution 

 of nodules identical in character with the original lesions. These 

 were most abundant in the liver and bone marrow but were also 

 present in other organs such as the spleen, the lungs and the 

 kidneys. 



Transplantation of material from an inguinal node gave a 

 vigorous growth in the original animal and attempts to transfer 

 the growth to other animals have apparently been successful. 



102 (1684) 

 The pharmacology of acetone. 



By WILLIAM SALANT and NATHANIEL KLEITMAN. 



[From the Department of Physiology and Pharmacology, University 

 of Georgia, Augusta, Georgia.] 



The action of acetone was studied on cats and dogs under light 

 ether anesthesia as well as on the isolated heart of the frog and 



1 See account of rabbit No. 1, Amer. Jour. Syph., 1921, v, 1. 



