\ 



Chemical Changes in Blood of Syphilitics. 213 



Summary of Results. — During the period of observation pre- 

 ceding the injections the values for urea nitrogen, sugar, and total 

 non-protein nitrogen of the blood were within the upper normal 

 limits given by Myers. 1 Three hours after the intravenous in- 

 jection of 6 decigram doses of arsphenamin, a slight rise in the 

 total non-protein nitrogen of the blood (2 or 3 mg.) was observed 

 in each of the two cases studied. This rise became more pro- 

 nounced one week later, reaching a value of about 38.0 mg. per 

 100 c.c. of blood, and then gradually declined. The injections 

 were repeated two weeks later. A more pronounced rise (up to 

 44 mg. per 100 c.c. of blood) was observed twenty-four hours 

 later — the immediate increase (three hours after injection) being 

 similar to that seen after the first injections. The changes in 

 the blood-urea nitrogen were, in general, parallel to the curves 

 of the total non-protein nitrogen. The individual values of the 

 former occasionally reached as high as 23 mg. per 100 c.c. of 

 blood and often constituted more than 60 per cent, of the latter. 

 Marked increases in the blood sugar were seen three hours or 

 within three to seven days after the injections. In one case the 

 blood sugar was more than doubled three hours after the injection. 

 In no case, however, did the blood sugar reach much above the 

 upper normal limit, — the value in the last case referred to being 

 153 mg. per 100 c.c. of blood. 



The authors wish to thank Dr. Jay F. Schamberg, Dr. John A. 

 Kolmer, and Dr. George W. Raiziss of this Institute for their 

 kind cooperation throughout the work. 



107 (1689) 



Chemical stimulation of the annelid nerve cord. 



By A. R. MOORE. 



[From the Physiological Laboratory of Rutgers College, 

 New Brunswick, N. J.] 



According to Maxwell's 2 classification, based on work with 

 mammals, there are two classes of excitants for nervous tissue, viz: 

 (1) those which act only upon the medullated fibers, such as the 



1 Myers, V. C. Chemical Changes in the Blood in Disease. Jour. Lab. and 

 Clinic. Med., 1920, v, 344. 



2 Maxwell, S. S., Am. J. Physiol, 1918, xlvii, 283. 



