2 5 6 



Scientific Proceedings (115). 



eluding both the local reaction and the subsequent course of the 

 disease. Especial attention was given to conditions which ap- 

 peared to influence either of these reactions and the results were 

 controlled by parallel observations on the reaction produced by 

 the infection of normal animals. 



While all of the details of the experiments are not as yet avail- 

 able, certain definite results may be recorded in so far as the local 

 reaction is concerned. Briefly, four general types of reaction were 

 observed : 



1. The first reaction consisted of a mild, acute inflammatory 

 process which was followed by a papular infiltration in the skin 

 associated with more or less enlargement and induration of the 

 regional lymph nodes. In its typical form, this reaction began 

 within 24 hours and reached its height within 5 to 7 days after 

 inoculation; it then subsided very rapidly, disappearing com- 

 pletely within 9 to 14 days after inoculation. 



2. A second form of reaction differed from that described above 

 in only one respect. With the fading of the cutaneous lesions, 

 there was only a partial resolution of the lymphadenitis followed 

 almost immediately by a progressive enlargement and induration 

 which resembled the satellite adenitis of a primary infection in 

 all essential respects. This condition persisted for weeks or even 

 months. 



3. W T ith a third group of animals, an additional feature was 

 introduced in the form of a diffuse or papular infiltration of the 

 skin at the site of inoculation. These lesions presented the ap- 

 pearance of early primary infiltrations or of the slight cutaneous 

 lesions frequently observed in primary infections and contained 

 actively motile spirochetes in abundance. The reaction was 

 usually manifest within 7 to 14 days; while the regional lymph 

 nodes exhibited a progressive and persistent enlargement and 

 induration, the cutaneous lesion was transient and usually dis- 

 appeared within 2 to 3 weeks. 



4. The fourth type of reaction was characterized by the de- 

 velopment of persistent cutaneous lesions associated with a pro- 

 nounced lymphadenitis. The cutaneous lesions assumed the form 

 of flattened or elevated papules varying from a few millimeters 

 to a centimeter in cross diameter or developed into large, well 



