260 Scientific Proceedings (115). 



resolution with a pronounced tendency to necrosis and central 

 softening. 



This was the condition of the animal 2 months after reinocula- 

 tion at which time a second group of lesions developed beginning 

 with a reinduration of the chancre and an increase of the lesions 

 in the left testicle. These were followed by the appearance of a 

 granuloma of the left tendo-Achillis and of large cutaneous granu- 

 lomata on the tail, on the left hind foot and a little later in both 

 scrota. All of these lesions are still present. 



The outstanding features of the infection in this animal are 

 the sequence of events and the type and destructiveness of the 

 lesions. The first unusual feature was the remarkably rapid 

 development of the chancre at approximately the same time with 

 a keratitis and extensive bone lesions. Obviously, the occurrence 

 of the chancre can be attributed to the reinoculation. If the 

 keratitis is also referred to the Nichols strain, its time of appear- 

 ance, 3 weeks after reinoculation, is the first instance of this kind 

 we have so far observed. On the other hand, if it is attributed 

 to the original inoculation, its occurrence 2Y2 months later, is 

 more in accord with our experience of the time relation of general- 

 ized lesions. The subsequent development of a number of promi- 

 nent cutaneous and tendon sheath lesions some weeks after the 

 keratitis, is another peculiar feature of this experiment, since eye 

 manifestations are usually terminal events of an infection. The 

 only bone lesions observed with the strain used for the primary 

 inoculation have been two instances of slight periosteal lesions 

 of the nasal bones and while destructive bone lesions are com- 

 paratively common with the Nichols strain of Treponema pallidum, 

 they have never reached the proportions of those observed in this 

 instance. In point of time, moreover, the occurrence of such bone 

 lesions 3 weeks after inoculation is unprecedented in our experience. 



The large cutaneous lesions which appeared some 2 months 

 after reinoculation are of the usual type observed with the Nichols 

 strain but differed markedly from the comparatively rare cuta- 

 neous lesions of Strain III, which are of the papular or infiltrative 

 type. Moreover, if these granulomata were due to the original 

 inoculation, they should have occurred some time before the 

 keratitis. In their type, time of occurrence and sequence rela- 



