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Anaphylactic Deaths in Guinea Pigs. 263 



still beating in the first one autopsied. In every way these pigs 

 resembled pigs dead of anaphylaxis. The wheal at the point of 

 inoculation had not materially changed in size, the inference being 

 that the 0.1 c.c. of the II per cent, egg albumin had been absorbed 

 in part only. 



No comment is made on this occurrence, and it is reported 

 only as a very peculiar accidental observation which is of great 

 importance to us in connection with the general question of 

 sudden anaphylactic death from minute doses of antigen injected 

 intracutaneously. It appears to be an example of acute death 

 in individual sensitized guinea pigs by the absorption from the 

 skin of very minute amounts of a reasonably pure protein. At- 

 tempts to repeat this result with a dozen guinea pigs, since that 

 time, have not succeeded. 



