Studies on Experimental Rickets. 275 



Further experiments are in progress to determine the limits 

 of acid and base administration, in which the above observations 

 hold, and to extend the study to various levels of Ca and P intake. 



Table I. 















Acid- 







Period. 



Date 



Vol. 



D. 



Ph. 



NH3 



ity c.c. 



P 



Ca 





Nov. 



c.c. 







gm. 



N/10 



gm. 



gm. 





14 



960 



1.020 



5-8 



1.42 



726 



2.06 



•394 





15 



1620 



1. 021 



5-9 



.91 



748 



1.66 



.376 





16 



1320 



1.023 



5-7 



1.20 



815 



1.99 



•455 





17 



1225 



1.025 



5-8 



1.20 



760 



1. 71 



.446 





18 



1950 



1. 019 



6-5 



•52 



400 



1.79 



.389 



II. is gm. NaHCOs. { 



19 



1850 



1. 021 



7.2 



.28 



120 



1.32 



.307 





20 



1700 



1.022 



7-3 



.21 



160 



1.41 



.297 





21 



1480 



1.024 



5-7 



.61 



508 



1.68 



.385 



III. 300 c.c. N/10HCI | 



22 



1075 



1.027 



5-3 



1.09 



800 



1.84 



.467 





23 



1250 



1.023 



4.9 



1.44 



850 



1.86 



•435 





24 



1320 



1.022 



4.9 



1.65 



787 



1.90 



.512 



Table II. 











Per 









Per 



3 Last Days 



P in 



P in 



Total 



Cent. 



Ca in 



Ca in 



Total 



Cent. 



of Period. 



Urine. 



Feces. 



P. 



in 



Urine. 



Feces. 



Ca. 



in 











Urine. 









Urine. 





5.36 



3-99 



9-35 



57 



1.27 



3-17 



4-44 



28.7 



II. 15 gm. NaHCOa. . . 



4-52 



4.72 



9.24 



44 



.99 



3-42 



4.41 



22.2 



III. 300 c.c. N/roHCl. . 



5.60 



3-53 



9-13 



61 



1.41 



2-94 



4-35 



32.4 



139 (1721) 



Studies on experimental rickets, IV. 

 Cod liver oil as contrasted with butter fat in the protection against 

 the effects of insufficient calcium in the diet. 



By E. V. McCOLLUM, NINA SIMMONDS, P. G. SHIPLEY 

 and E. A. PARK. 



[From the Laboratory of the Department of Chemical Hygiene, School 

 of Hygiene and Public Health, and from the Department 

 of Pediatrics, Johns Hopkins University, Baltimore.} 



In our experimental work we have made observations which 

 demonstrate in a striking way the differences in the effectiveness 



