290 



Scientific Proceedings (115). 



147 (1729) 



Studies in the physiology of vitamins. II, Does vitamin-B 

 stimulate glands in a manner similar to 

 the alkaloid pilocarpine? 



By GEORGE R. COWGILL. 



[From the Sheffield Laboratory of Physiological Chemistry 

 in Yale University, New Haven, Conn.] 



The hypothesis 1 that vitamin-B functions to stimulate glands 

 in a manner similar to the alkaloid pilocarpine has been investi- 

 gated experimentally. Extracts of rice polishings, wheat embryo, 

 navy bean and yeast, and neutralized tomato juice, all of which 

 were demonstrated to contain vitamin-B by tests on polyneuritic 

 animals (pigeons and dogs), were examined for their action on the 

 secretory function of the salivary glands. The effect of intra- 

 venous injection of these products on the flow of saliva was noted 

 in anesthetized dogs in which the ducts of the submaxillary and 

 sublingual glands were cannulized. In order to ascertain whether 

 any slight temporary flow of saliva that might follow the injection 

 was due to a vaso-dilator effect of the injected product on the 

 sympathetic nervous system, blood pressure was determined by 

 means of a manometer connected with the femoral artery. Nor- 

 mal dogs and polyneuritic dogs were used. 



All of these products gave negative results. Stimulation of 

 the chorda tympani nerve or injection of pilocarpine, however, 

 always produced a characteristic flow. 



148 (1730) 



A contribution to the study of the relationship between vitamin-B 

 and the food intake in the dog. 



By GEORGE R. COWGILL. 



[From the Sheffield Laboratory of Physiological Chemistry 

 in Yale University, New Haven, Conn.] 



Karr 2 showed that in the dog some relationship exists between 



1 Uhlmann, Zeitsch. f. Biol., 1918, lxviii, 3. 

 1 Karr, Jour. Biol. Chem., 1920, xlviv, 255. 



