314 



Scientific Proceedings (116). 



Salvarsan injected intravenously into rabbits in large doses 

 causes intravascular agglutination which may be observed in the 

 drawn blood. The lungs of such animals are rilled with petechial 

 hemorrhages resulting from emboli of the agglutinated red cells, 

 and the animals die acutely. 



A certain proportion of animals injected at three-day intervals 

 with sub-lethal doses die during the third or fourth injection in a 

 manner resembling the death of animals injected with large doses. 

 In these animals also the anatomical evidences of intravascular 

 agglutination and pulmonary embolism are constantly present. 



The total sum of these repeated doses barely reaches the con- 

 centration found necessary for immediate intravascular agglutina- 

 tion, and as this total sum must be considerably reduced by the 

 excretion of salvarsan during the six or nine days intervening, 

 some additional factor must be responsible for the sudden occurr- 

 ence of intravascular agglutination in these animals. 



Examination of their blood shows no increase in the agglutin- 

 ability of the red cells during the course of the injections, but there 

 is a distinct drop, in some cases to one-sixteenth of the original 

 value, in the power of the serum to inhibit, in vitro, the agglutina- 

 tion of red cells by salvarsan. 



164 (1746) 



Impure and misnamed stock cultures of obligate anaerobes. 



By IVAN C. HALL. 



[From the Department of Bacteriology and Experimental Pathology, 

 University of California.] 



During the past few years the writer has engaged in building 

 up a collection of cultures of obligate anaerobes whose purity and 

 true identity should be, if possible, beyond question. In addition 

 to numerous cultures isolated from original sources a number have 

 been received from other laboratories. Most of these were al- 

 ready labelled as to species and form the subject of this report. 



While a few cultures were received with aerobic contamination 

 these are not included here since aerobic contaminations are 



