NETLEY HOSPITAL (1896) 



235 



Journal, 30th January 1897. Eighteen men 

 offered themselves — 



" A good deal of fever was developed in all 

 cases, and sleep was a good deal disturbed. These 

 constitutional symptoms had to a great extent 

 passed away by the morning, and laboratory work 

 went on without interruption. . . . With two excep- 

 tions, all these vaccinations were performed upon 

 Medical Officers of the Army or Indian Medical 

 Services, or upon Surgeons on Probation who were 

 preparing to enter those services." 



Good luck attend all eighteen of them, and im- 

 munity against typhoid, wherever they are. The 

 doses that they received were estimated in propor- 

 tion to the dose that would kill a guinea-pig of 350- 

 400 grammes weight ; and the protective fluid 

 contained no living bacilli : — 



" The advantages which are associated with the 

 use of such * dead vaccines ' are, first, that there is 

 absolutely no risk of producing actual typhoid fever 

 by our inoculations ; secondly, that the vaccines 

 may be handled and distributed through the post 

 without incurring any risk of disseminating the 

 germs of the disease ; thirdly, that dead vaccines 

 are probably less subject to undergo alterations in 

 their strength than living vaccines." 



The first use of the vaccine during an outbreak 

 of typhoid was in October 1897, at tne Kent 

 County Lunatic Asylum. The treatment was 



