2nd. That it misrepresents the preparation in organic constitu- 

 ents in the statement that "LLOYD'S HYDRASTIS" does not con- 

 tain an appreciable amount of the White ilkaloid of Hydrastis, a 

 principle to which the preparation is largely supposed to owe it's 

 medicinal properties and which, we assert, is invariably present 

 therein in abundance. 



3d. That the statement by Prof. Norton, that the precipitate 

 thrown down from LLOYD'S HYKRASTIS, by Ammonia-water, 

 is "a mixture of hydrate of Alumina and hydrate of Magnesia," 

 is incorrect. Such a precipitate contains not only portions of the 

 White Alkaloid of Hydrastis, but without exception is composed very 

 largely of CALCITJM Compounds. 



4th. That Prof. Norton furnished this false analysis to a business 

 rival of our house for a consideration, and when his attention was 

 called, by us, upon its first appearance, and in a generous manner 

 (see our letter herewith), to the fact that it did not at all represent 

 the preparation, he refused to reconsider or correct it, but referred 

 all questions concerning his own responsibility as a chemist to the 

 party who employed him to make the report. 



In support of our charges against Prof. Norton, we beg to present the 

 following evidence. 



1st. Our letter to Prof. Norton (enclosed herewith), and his reply, 

 which we append. 



(COPY.) 



Massachusetts Institute or Technology. 



Boston, March 12th, 1888. 



Lloyd Brothers, 



Cincinnati. 



Gentlemen : — In regard to all questions relating to the analysis of the 

 sample of hydrastis mentioned in your letter of March 8, 1888, I must 

 refer you to the Wm. 8. Merrell Chemical Co. of your city, by whom I 

 was employed to make the analysis. * 



Yours very truly, 



Lewls M. Norton. 



2nd. Analysis by Edward S. Wo(>d, M. D., Phof. of Chemistry, 

 Chemical Laboratory, Harvard Medical College. 



"I bought of Messrs. T. Metcalf & Co., a bottle of Lloyd's Hydrastis, 

 on March 30th, and have analyzed the same for the purpose of ascer- 

 taining whether it contains anv alkaloid or not, and, if so, what alkaloid 

 was present." (Here follow the tests that were used and the results.) 

 "From my results I have no hesitation in reporting that the preparation 

 of Lloyd's Hydrastis, procured by me in the open market, contained 

 a very considerable proportion cf the alkaloid hydrastine. All the 



» We challeiigpa the men he refers to as his employers, by a S3,n00 forfeit, to 

 protect their ai'alysl; they dedined, and Prof. Norton has ro right to refer us 

 to persoi s who deserted him after malieioiisly iisinft iiis i ame and lhat of your 

 worthy insliiullon, in a public attempt to injure our eliuracter. 



— 3 — 



reactions could be obtained with the alkaloidal residue from about fifteen 

 cubic centimeters of Lloyd's Hydrastis, showing that a large amount of 

 alkUoid is contained in the. preparation. 1 made no attempt to measure it 

 quantitatively." 



3d. Analysis by B. F. Davenport, M. D., State Analyst, Boston, 

 Ma.ss., (Member of the American Chemical Society, also of Lon- 

 don, Paris and Berlin, of the British Society of Public Analysts;, 

 also German Society of Analytical Chemists, Late Prop, of An- 

 alytical Chemistry, Mass. College of Pharmacy.) 



"I have personally purcha.sed, of B. O. & G. C. Wilson, of Boston, an 

 original, unopened, sealed one-pint bottle of Lloyd's Hydrastis and 

 have opened and tested it, with the following results. It contains a 

 white alkaloid which crystallizes out from alcohol and responds in its 

 reaction to those characteristic of Hydrastine, the white alkaloid of 

 Hydrastis Canadensis, as given in Dr. A. B. Prescott's work on 'Organic 

 Analysis.' " 



4th. Analysis by Edgar L. Patch, Professor of Theory and 

 Practice of Pharmacy, Massachu-setts College of Ppiarmaoy', 

 AND Director of the Pharmaceutical Laboratory, Boston, Mass. 



"I have purchased an original bottle of Lloyd's Hydrastis, and have 

 personally examined the same for the presence of Hydrastine, the 

 white alkaloid of Hydrastis Canadensis. The alkaloid I find to be 

 present, and have satisfactorily determined and separated it." 



5lh. Analysis by Edward W. Eunyon, Ph. G., Dean op the Fac- 

 ulty OP THE California College of Pharmacy, San Francisco, 

 Cal. 



"I purchased in this market a bottle of Lloyd's Hydrastis, I removed 

 the metal cap, withdrew the cork, and carefully tested the contents for 

 the alkaloid Hydrastine, and I found a large quantity of this alkaloid.''' 



6th. Analysis BY^ Curtis C. Howard, M. Sc., Professor op Chemis- 

 try AND. Toxicology, Starling Medical College, Columbus, 0. 



"I have examined a bottle of Lloyd's Hydrastis, that I obtained of 

 a wholesale drug house in Columbus. I find it to contain the alkaloid 

 Hydrastine in considerable quantity." 



7th. Analysis by Robert B. Warder, Professor op Chemistry, 

 Howard University, Washington, D. C. 



"I have purchased a bottle of Lloyd's Hydrastis, in the original 

 wrapper, from the stock of a Washington druggist, and immediately 

 after otiening the bottle I tested the contents myself, as follows : In the 

 examination for Hydrastine I added a few drops of Mayer's solution 

 to .5 c. c. of Lloyd's Hydbastls, which immediately gave an abundant 

 while alkaloidal precipitate entirely soluble in an equal volume of alcohol. 



' This precipitate upon examination proved to be a hydrastine com- 

 pound. The alkaloid was separated from other portions of Lloyd's 

 Hydrastis, purified, and conclusively shown to conform to the recorded 

 reactions of hydrastine" (detail tests were given). 



