460 



TR YPA NO SO MI DM 



lesions. Halberstadter has obtained a general eruption in ourang- 

 outangs. According to Castellani's experiments, splenic blood, ob- 

 tained by puncturing the spleen of a patient affected with fram- 

 boesia, can reproduce the disease in monkeys. The inoculation of 

 the blood of the general circulation also may occasionally produce 

 the disease. The inoculation of cerebro-spinal fluid into normal 

 monkeys has always proved negative. 



Neisser, Halberstadter, J. Prowazek in Java, and later Castellani 

 in Ceylon, have proved that monkeys successfully inoculated with 

 f ramboesia do not thereby become immune to syphilis, and, vict 

 versa, monkeys successfully inoculated with syphilis do not thereby 

 become immune to f ramboesia. According to Levaditi, monkeys 

 immunized for frambcesia do not acquire any immunity for syphilis. 



Fig. 142. — Monkey inoculated with 

 Frambcesia. 



but mohkeys immunized for syphilis may acquire a partial immunity 

 for frambcesia. According to Ashburn and Craig, monkeys of the 

 species Cynomolgus philippinensis are susceptible to frambcesia, but 

 not to syphilis. 



The following facts are in favour of the T. pertenue being the 

 specific cause of frambcesia : — 



1. In the non-ulcerated papules, in the spleen, in the lymphatic 

 glands of frambcesia patients, as well as in inoculated monkeys, the 

 T. pertenue is the only organism present. No other germ can be 

 demonstrated, either microscopically or by cultural methods. 



2. The extract of frambcesia material containing the T . pertenue — • 

 but, so far as our present methods of investigation permit us to say, 

 no other germs — is effective when inoculated into monkeys. 



3. The extract of frambcesia material from which the T, pertenue 



