MADURELLA TOZEURI 



1107 



sometimes even 5 microns in diameter. Sclerotes are only rarely 

 produced, and then they appear on the surface of the medium. 

 Occasionally it gives rise to a mycetoma in man, in which it forms 

 black amorphous grains, which are often made up of mycelial rings, 

 enclosing some degenerate cellular elements, which are impregnated 

 with the pigment of the fungus, and also of small diffuse masses, 

 formed solely by the filaments of the fungus, which have a yellow 

 membrane. Inoculation into pigeons positive. Isolated by Nicolle 

 from a mycetoma at Tozeur. 



Genus Indiella Brumpt, 1906. 



Definition. — -Arthrosporinese with septate, ramified hyphae, with- 

 out black pigment, and hence sclerotia white. or yellowish. 



Type Sj)ecies,— 'Indiella nansoni Brumpt, 1906. 



Remarks.— White thallus, living parasitic in various animal 

 tissues — -connective tissue, muscles, and bones. Mycelial threads 

 1-8 or 10 [jb, septate, ramified, never secreting — -in contrast to 

 the fungi of genus Madurella — -any black pigment. Masses of 

 mycelial threads form sclerotia-like bodies or grains of various shape 

 containing chlamydospores. 



Classification. — -The species may be recognized as follows : — ■ 



A. Sclerotia hard and bean-shaped — Mansoni. 



B. Sclerotia soft and in coiled masses — Reynieri. 



Indiella mansoni Brumpt, 1906. 



Mycelial threads are septated, white, thin, 1-5-2 fi when young, 

 larger (3-5 ^) and of irregular shape when old. Numerous spherical 

 chlamydospores, generally terminal, 5-12 ^ in diameter. Grains 

 (sclerotia) very small, of i-J millimetre, white, lenticular or reni- 

 form, very hard, do not soften by keeping in caustic potash. The 

 fungus has not been grown. 



Pathogenicity. — -It is the cause of Manson's white mycetoma, of 

 which only one case is known. 



Indiella reynieri Brumpt, 1906. 



White thallus. Most mycelial filaments are very thin, ^, 

 septated; some — -those at the periphery — -are of irregular shape, 

 much broader (4-5 /^), moniliform. Nearly every mycelial thread 

 has at the peripheral extremity a terminal chlamydospore, 5-20 jjb, 

 often septate in two or three cells. Grains or sclerotia are small, 

 less than i millimetre in diameter, coiled up like the excrementa 

 of earth-worms. 



Pathogenicity. — ^This fungus causes a variety of mycetoma with 

 white grains (Reynier's white mycetoma), of which there is only one 

 case on record — a European patient who had never left France. 

 The case was observed and reported on by Reynier. 



